Despite significant advances in research, the prognosis for both primary and secondary
brain cancers remains poor. The blood-brain barrier (BBB) is a complex and unique semi …

Gliomas are the most common tumor of the central nervous system. However, the presence
of the brain barrier blocks the effective delivery of drugs and leads to the treatment failure of …

Aging is an inevitable and progressive biological process involving dysfunction and
eventually destruction of every tissue and organ. This process is driven by a tightly regulated …

Human mesenchymal stem cells (MSCs) have an intrinsic property for homing towards
tumor sites and can be used as tumor‐tropic vectors for tumor therapy. But very limited …

Abstract Naringin (4′, 5, 7-trihydroxyflavanone 7-rhamnoglucoside), a natural flavonoid,
has pharmacological properties. In the present study, we investigated the anti-metastatic …

Successful therapy and diagnosis of glioma is one of the biggest challenges in the
biomedical fields. The incidence is growing gradually around the world. Annually, there are …

Multifunctional nanoplatforms combining versatile therapeutic modalities with a variety of
imaging options have the potential to diagnose, monitor, and treat brain diseases. The …

Abstract Forkhead box protein 3 (Foxp3) is known as a specific marker for regulatory T cells
which contribute to immunosuppression in tumor microenvironment. However, existing …

Transforming growth factor (TGF)-β-activating kinase 1 (TAK1) is a serine/threonine kinase
which is frequently associated with human cancer progression. However, its functional role …

Glioblastoma multiforme (GBM) is the worst and most common brain tumor, characterized by
high proliferation and invasion rates. Nanoparticles of biodegradable polymers for …