The role of gut microbiota in tumor immunotherapy

M Wu, J Bai, C Ma, J Wei, X Du - Journal of Immunology …, 2021 - Wiley Online Library
Tumor immunotherapy is the fourth therapy after surgery, chemotherapy, and radiotherapy. It
has made great breakthroughs in the treatment of some epithelial tumors and hematological …

The role of toll-like receptors (TLRs) mediated inflammation in pancreatic cancer pathophysiology

A Orlacchio, P Mazzone - International Journal of Molecular Sciences, 2021 - mdpi.com
Pancreatic cancer (PC) is one of the most lethal forms of cancer, characterized by its
aggressiveness and metastatic potential. Despite significant improvements in PC treatment …

New treatment options in metastatic pancreatic cancer

M Fudalej, D Kwaśniewska, P Nurzyński… - Cancers, 2023 - mdpi.com
Simple Summary The poor prognosis of pancreatic cancer (PC) is associated with several
factors, such as diagnosis at an advanced stage, early distant metastases, and remarkable …

Exploring the potential role of the gut microbiome in chemotherapy-induced neurocognitive disorders and cardiovascular toxicity

S Ciernikova, M Mego, M Chovanec - Cancers, 2021 - mdpi.com
Simple Summary While lifesaving achievements have allowed cancer to be cured in many
patients, survivors cured of cancer may suffer from long-term adverse treatment sequelae …

The heterogeneity of the tumor microenvironment as essential determinant of development, progression and therapy response of pancreatic cancer

Group Young Researchers in Inflammatory … - Cancers, 2021 - mdpi.com
Simple Summary Pancreatic ductal adenocarcinoma (PDAC) is still one of the deadliest
cancers in western countries. It is commonly diagnosed at advanced stages and most anti …

The impact of the microbiome on resistance to cancer treatment with chemotherapeutic agents and immunotherapy

A Sevcikova, N Izoldova, V Stevurkova… - International Journal of …, 2022 - mdpi.com
Understanding the mechanisms of resistance to therapy in human cancer cells has become
a multifaceted limiting factor to achieving optimal cures in cancer patients. Besides genetic …

Gut microbiota–microRNA interactions in intestinal homeostasis and cancer development

N Nikolaieva, A Sevcikova, R Omelka, M Martiniakova… - Microorganisms, 2022 - mdpi.com
Pre-clinical models and clinical studies highlight the significant impact of the host–
microbiota relationship on cancer development and treatment, supporting the emerging …

Microbiota regulates pancreatic Cancer carcinogenesis through altered immune response

Y Chai, Z Huang, X Shen, T Lin, Y Zhang, X Feng… - Microorganisms, 2023 - mdpi.com
The microbiota is present in many parts of the human body and plays essential roles. The
most typical case is the occurrence and development of cancer. Pancreatic cancer (PC), one …

Role of microbiota and microbiota‐derived short‐chain fatty acids in PDAC

HY Temel, Ö Kaymak, S Kaplan, B Bahcivanci… - Cancer …, 2023 - Wiley Online Library
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive lethal diseases
among other cancer types. Gut microbiome and its metabolic regulation play a crucial role in …

Insights into the role of gut and intratumor microbiota in pancreatic ductal adenocarcinoma as new key players in preventive, diagnostic and therapeutic perspective

C Panebianco, D Ciardiello, A Villani… - Seminars in Cancer …, 2022 - Elsevier
Microbiota consists of a dynamic organization of bacteria, viruses, archaea, and fungal
species involved in a number of vital functions spanning from the digestion of carbohydrates …