Potential cardioprotective effect of octreotide via NOXs mitigation, mitochondrial biogenesis and MAPK/Erk1/2/STAT3/NF-kβ pathway attenuation in isoproterenol …

AA Khalifa, NH El Sokkary, SS Elblehi, MA Diab… - European Journal of …, 2022 - Elsevier
Myocardial infarction (MI) is a global health care problem, which instigates irreversible
cardiac tissue damage and sudden death, necessitating new prevention and management …

The Role of Hypothalamic Neuropeptides in Regulation of Liver Functions in Health and Disease

AD Petrescu, SY An, J Venter, M McMillin, S DeMorrow - Endocrines, 2023 - mdpi.com
The communication between brain and peripheral tissues is mediated by neuropeptides that
coordinate the functions of each organ with the activities of the entire body in specific …

Pore change during degradation of octreotide acetate-loaded PLGA microspheres: The effect of polymer blends

T Wang, P Xue, A Wang, M Yin, J Han, S Tang… - European Journal of …, 2019 - Elsevier
The purpose of this study was to solve the plateau phase (the stage in which the drug in the
microsphere undergoes a slow release or almost no release after initial release) problem by …

Hepatoprotective effect of limonene against chronic immobilization induced liver damage in rats

R Amini, M Asle-Rousta, S Aghazadeh - Naunyn-Schmiedeberg's archives …, 2020 - Springer
Prolonged immobilization may impair the physiological functions of various organs of the
body, including the liver, brain, and heart. In this study, we investigated the hepatoprotective …

Octreotide and lanreotide decrease ovarian ischemia–reperfusion injury in rats by improving oxidative and nitrosative stress

S Kalyoncu, B Yilmaz, M Demir… - Journal of Obstetrics …, 2020 - Wiley Online Library
Aim To investigate the protective effect of octreotide and lanreotide on ovarian damage in
experimental ovarian ischemia–reperfusion injury. Methods Fifty‐six rats were separated …

Is There a Place for Somatostatin Analogues for the Systemic Treatment of Hepatocellular Carcinoma in the Immunotherapy Era?

E Kouroumalis, I Tsomidis, A Voumvouraki - Livers, 2022 - mdpi.com
Patients with advanced hepatocellular carcinoma (HCC) have a very limited survival rate
even after the recent inclusion of kinase inhibitors or immune checkpoint inhibitors in the …

Restraint stress alters expression of glucocorticoid bioavailability mediators, suppresses Nrf2, and promotes oxidative stress in liver tissue

HJC Chen, T Yip, JK Lee, J Juliani, C Sernia, AF Hill… - Antioxidants, 2020 - mdpi.com
Hepatic glutathione synthesis and antioxidant protection are critically important for efficient
detoxification processes in response to metabolic challenges. However, this biosynthetic …

Protective Role of Somatostatin in Sepsis‐Induced Intestinal Barrier Dysfunction through Inhibiting the Activation of NF‐κB Pathway

X Xu, Q Zhu, G Li, J Ma, Z Pan… - … Research and Practice, 2020 - Wiley Online Library
Somatostatin (SST) has a protective role in intestinal injury, inflammatory response, and
intestinal mucosal barrier in rats with acute pancreatitis. However, its function in sepsis …

Repeated acute stress modulates hepatic inflammation and markers of macrophage polarisation in the rat

JG Spiers, N Steiger, A Khadka, J Juliani, AF Hill… - Biochimie, 2021 - Elsevier
Bidirectional communication between the neuroendocrine stress and immune systems
permits classically anti-inflammatory glucocorticoids to exert pro-inflammatory effects in …

Chronic variable stress induces hepatic Fe (II) deposition by up-regulating ZIP14 expression via miR-181 family pathway in rats

S Jiang, T Guo, S Guo, J Gao, Y Ni, W Ma, R Zhao - Biology, 2021 - mdpi.com
Simple Summary Modern intensive production methods attract accusations of poor animal
welfare due to long-term exposure to stressors including high temperature, persistent …