Background: Diclofenac is a proven, commonly prescribed nonsteroidal anti-inflammatory
drug (NSAID) that has analgesic, anti-inflammatory, and antipyretic properties, and has been …

Nitric oxide (NO) is involved in many physiological processes and several lines of evidence
have indicated that NO plays a complex and diverse role in the modulation of pain. Nitric …

Four families of potassium channels with different structures, functional characteristics and
pharmacological sensitivity, are distinguished in neurons: voltage-gated (Kv), calcium …

Prasanna N, Subbarao CV, Gutmann JL. The efficacy of preoperative oral medication of
lornoxicam and diclofenac potassium on the success of inferior alveolar nerve block in …

Pain is a classical sign of inflammation, and sensitization of primary sensory neurons (PSN)
is the most important mediating mechanism. This mechanism involves direct action of …

Non-opioid analgesics including both selective and non-selective cyclooxygenase (COX)
inhibitors and acetaminophen are the most widely used treatments for pain. Inhibition of …

Background. The aim of the study was to evaluate the effect of lornoxicam (L) on sensory
and motor block onset time, tourniquet pain, and postoperative analgesia, when added to …

The pyrazol compounds are known to possess antipyretic, analgesic and anti-inflammatory
activities. This study was conducted to investigate the peripheral antinociceptive effect of the …

Monosodium glutamate (MSG) is a widely used food additive. Although it is generally
considered safe, some questions regarding the impact of its use on general health have …

The present study investigates the involvement of the l-arginine-Nitric Oxide-cGMP-K+ ATP
pathways responsible for the action of anti-allodynic and antihyperalgesic activities of …