Executive summary Every infant, child, and adolescent will experience pain at times
throughout their life. Childhood pain ranges from acute to chronic, and includes procedural …

Introduction: Given our improved understanding of the role of central sensitization (CS) in
many patients with chronic pain, it seems rational to account for CS during treatment. Areas …

Background: Emotional disorders are common comorbid affectations that exacerbate the
severity and persistence of chronic pain. Specifically, depressive symptoms can lead to an …

Background This is an update of the original Cochrane review first published in Issue 1,
2003, and previously updated in 2009, 2012 and 2014. Chronic pain, defined as pain that …

Background Pain is a common feature of childhood and adolescence around the world, and
for many young people, that pain is chronic. The World Health Organization guidelines for …

Chronic pain is a serious public health problem with a strong affective-motivational
component that makes it difficult to treat. Most patients with chronic pain suffer from severe …

We know little about the safety or efficacy of pharmacological medicines for children and
adolescents with chronic pain, despite their common use. Our aim was to conduct an …

Background Pain is a common feature of childhood and adolescence around the world, and
for many young people, that pain is chronic. The World Health Organization guidelines for …

Chronic pain in childhood is an international public health problem. We conducted a
systematic review and meta-analysis to provide a summary of the published evidence of …

Chronic pain in children and adolescents is a common and debilitating health problem. This
narrative review will give a brief overview on what pediatric chronic pain is and what …