Regulation of ErbB Receptors by the Ca2+ Sensor Protein Calmodulin in Cancer

A Villalobo - Biomedicines, 2023 - mdpi.com
Overexpression and mutations of the epidermal growth factor receptor (EGFR/ErbB1/HER1)
and other tyrosine kinase receptors of the ErbB family (ErbB2/HER2, ErbB3/HER3 and …

The role of CaMKK2 in Golgi-associated vesicle trafficking

G Kennedy, O Gibson, D T. O'Hare… - Biochemical Society …, 2023 - portlandpress.com
Calcium/calmodulin-dependent protein kinase kinase 2 (CaMKK2) is a serine/threonine-
protein kinase, that is involved in maintaining various physiological and cellular processes …

Dihydroartemisinin inhibits liver cancer cell migration and invasion by reducing ATP synthase production through CaMKK2/NCLX

J Chang, C Xin, Y Wang, Y Wang - Oncology Letters, 2023 - spandidos-publications.com
Calcium/calmodulin‑dependent protein kinase kinase 2 (CaMKK2) and mitochondrial
sodium/calcium exchanger protein (NCLX) are key regulatory factors in calcium …

[HTML][HTML] Calcium signals and potential therapy targets in ovarian cancer

F Deng, M Fu, C Zhao, J Lei, T Xu… - International …, 2023 - spandidos-publications.com
Ovarian cancer (OC) is a deadly disease. The poor prognosis and high lethality of OC are
attributed to its high degrees of aggressiveness, resistance to chemotherapy and recurrence …

PFKP Lactylation Promotes the Ovarian Cancer Progression Through Targeting PTEN

J Mi, L Zhao, Y Shen, S Mo, Y Kuang - Biochemical Genetics, 2024 - Springer
Ovarian cancer (OC) ranks among the most prevalent malignancies affecting females
globally and is a leading cause of cancer-related mortality in women. This study sought to …

[HTML][HTML] The mutual interaction of TRPC5 channel with polycystin proteins

M Kwak, H Kang, J Kim, Y Hong… - The Korean Journal …, 2024 - pmc.ncbi.nlm.nih.gov
PKD1 regulates a number of cellular processes through the formation of complexes with the
PKD2 ion channel or transient receptor potential classical (TRPC) 4 in the endothelial cells …

[HTML][HTML] Distinguishing parallel from series circuits with a double knockdown procedure in human cell lines

AM Gocher-Demske, S Dai, AM Edelman - STAR protocols, 2022 - Elsevier
Signaling cascades can act in series or in parallel. Here, we describe a convenient and
robust protocol for dual, sequential knockdown of two proteins using RNA interference. We …

Defining the SPCA2C interactome identifies unique links to store-operated calcium entry

P Samardzija, MA Fenech, R Lang, MKC Carter… - bioRxiv, 2023 - biorxiv.org
Calcium (Ca2+) is critical for normal cell function and several protein networks are required
for Ca2+ signaling. In the pancreas, regulated changes in cytosolic Ca2+ allow for the …

Synergistic Drug Combination Treatments reveal Signaling Pathways involving CaMKK2

M Steckiewicz - 2022 - search.proquest.com
Over 500 protein kinases, over 50 phosphatases and numerous accessory proteins are
important signaling regulators of eukaryotic cellular activity. Over the course of evolution …