Adenosine triphosphate (ATP)-binding cassette (ABC) transporters may play an important
role in the pathogenesis of atherosclerotic vascular diseases due to their involvement in …

Pathological (ectopic) mineralization of soft tissues occurs during aging, in several common
conditions such as diabetes, hypercholesterolemia, and renal failure and in certain genetic …

ABCC6 deficiency promotes ectopic calcification; however, circumstantial evidence
suggested that ABCC6 may also influence atherosclerosis. The present study addressed the …

Soft tissue calcification occurs in several common acquired pathologies, such as diabetes
and hypercholesterolemia, or can result from genetic disorders. ABCC6, a transmembrane …

Pseudoxanthoma elasticum (PXE) is a rare genetic condition primarily caused by hepatic
ABCC6 transporter dysfunction. Most clinical manifestations of PXE are due to premature …

Pseudoxanthoma elasticum is a heritable disease caused by ABCC6 deficiency. Patients
develop ectopic calcification in skin, eyes, and vascular tissues. ABCC6, primarily found in …

Physiological calcification of soft tissues is a common occurrence in aging and various
acquired and inherited disorders. ABCC6 sequence variations cause the calcification …

Background Pseudoxanthoma elasticum (PXE) is characterized by progressive ectopic
mineralization of elastic fibers in dermal, ocular and vascular tissues. No effective treatment …

Ectopic mineralization-inappropriate biomineralization in soft tissues-is a frequent finding in
physiological aging processes and several common disorders, which can be associated …

Liver fibrosis is associated with arterial calcification (AC). Since the liver is a source of
inorganic pyrophosphate (PPi), an anti-calcifying compound, we investigated the …