Restoration of metal homeostasis: A potential strategy against neurodegenerative diseases

YY Zhang, XS Li, KD Ren, J Peng, XJ Luo - Ageing Research Reviews, 2023 - Elsevier
Metal homeostasis is critical to normal neurophysiological activity. Metal ions are involved in
the development, metabolism, redox and neurotransmitter transmission of the central …

From oxidative stress to metabolic dysfunction: The role of TRPM2

YS Li, HC Ren, H Li, M Xing, JH Cao - International Journal of Biological …, 2025 - Elsevier
Metabolic syndromes including atherosclerosis, diabetes, obesity, and hypertension are
increasingly prevalent worldwide. The disorders are the primary attributes of oxidative stress …

[HTML][HTML] Deletion of Calhm2 alleviates MPTP-induced Parkinson's disease pathology by inhibiting EFHD2-STAT3 signaling in microglia

X Bo, F Xie, J Zhang, R Gu, X Li, S Li, Z Yuan… - Theranostics, 2023 - ncbi.nlm.nih.gov
Background: Neuroinflammation is involved in the development of Parkinson's disease (PD).
Calhm2 plays an important role in the development of microglial inflammation, but whether …

Neuroprotective Potential of HC070, a Potent TRPC5 Channel Inhibitor in Parkinson′ s Disease Models: A Behavioral and Mechanistic Study

B Vaidya, I Roy, SS Sharma - ACS Chemical Neuroscience, 2022 - ACS Publications
Transient receptor potential canonical 5 (TRPC5) channels are predominantly expressed in
the striatum and substantia nigra of the brain. These channels are permeable to calcium …

Deletion of the transient receptor potential melastatin 2 gene mitigates the 6-hydroxydopamine-induced Parkinson's disease–like pathology

AFF Ferreira, H Ulrich, Y Mori, ZP Feng, HS Sun… - Molecular …, 2024 - Springer
Pharmacological inhibition of the transient receptor potential melastatin 2 (TRPM2), an
oxidative stress–activated calcium channel, was previously reported to be protective in …

Genetic knockout of TRPM2 increases neuronal excitability of hippocampal neurons by inhibiting Kv7 channel in epilepsy

Y Ying, L Gong, X Tao, J Ding, N Chen, Y Yao… - Molecular …, 2022 - Springer
Epilepsy is a chronic brain disease that makes serious cognitive and motor retardation. Ion
channels affect the occurrence of epilepsy in various ways, but the mechanisms have not yet …

The transient receptor potential melastatin 2: a new therapeutical target for Parkinson's disease?

AFF Ferreira, LRG Britto - Neural Regeneration Research, 2023 - journals.lww.com
The transient receptor potential melastatin 2 is a calcium-permeable cation channel member
of the TRP family. Also known as an oxidative stress-activated channel, the transient …

[HTML][HTML] Thyroid Hormone Supplementation Restores Cognitive Deficit, Insulin Signaling, and Neuroinflammation in the Hippocampus of a Sporadic Alzheimer's-like …

P Sepúlveda, AFF Ferreira, C Sandoval, G Bergoc… - Cells, 2024 - mdpi.com
Thyroid hormones play a crucial role in the development of the central nervous system and
are considered pivotal to cognitive functions in the adult brain. Recently, thyroid dysfunction …

Inhibition of neuroinflammation by GIBH-130 (AD-16) reduces neurodegeneration, motor deficits, and proinflammatory cytokines in a hemiparkinsonian model

ME Bianchetti, AFF Ferreira, LRG Britto - Frontiers in Neuroanatomy, 2024 - frontiersin.org
Parkinson's disease (PD) is a neurodegenerative condition characterized by the loss of
dopaminergic neurons in the substantia nigra pars compacta (SNc) of the brain, manifesting …

Neurodegeneration and glial morphological changes are both prevented by TRPM2 inhibition during the progression of a Parkinson's disease mouse model

AFF Ferreira, H Ulrich, ZP Feng, HS Sun… - Experimental Neurology, 2024 - Elsevier
Parkinson's disease (PD) is a neurodegenerative disease characterized by dopaminergic
neuron death and neuroinflammation. Emerging evidence points to the involvement of the …