Stress and anxiety have intertwined behavioral and neural underpinnings. These
commonalities are critical for understanding each state, as well as their mutual interactions …

Stress is recognized as an important issue in basic and clinical neuroscience research,
based upon the founding historical studies by Walter Canon and Hans Selye in the past …

Dysregulated prefrontal control over amygdala is engaged in the pathogenesis of psychiatric
diseases including depression and anxiety disorders. Here we show that, in a rodent anxiety …

The amygdala has long been associated with emotion and motivation, playing an essential
part in processing both fearful and rewarding environmental stimuli. How can a single …

Since the pioneering work of Penfield and his colleagues in the 1930s, the somatosensory
cortex, which is located on the postcentral gyrus, has been known for its central role in …

Although anxiety disorders represent a major societal problem demanding new therapeutic
targets, these efforts have languished in the absence of a mechanistic understanding of this …

Once acquired, a fearful memory can persist for a lifetime. Although learned fear can be
extinguished, extinction memories are fragile. The resilience of fear memories to extinction …

The amygdala is composed of multiple nuclei with unique functions and connections in the
limbic system and to the rest of the brain. However, standard in vivo neuroimaging tools to …

Brain systems that promote the maintenance of homeostasis in face of stress have
significant adaptive value. A growing body of work across species demonstrates a critical …

The stereotyped features of neuronal circuits are those most likely to explain the remarkable
capacity of the brain to process information and govern behaviors, yet it has not been …