Mechanisms of synaptic transmission dysregulation in the prefrontal cortex: pathophysiological implications
The prefrontal cortex (PFC) serves as the chief executive officer of the brain, controlling the
highest level cognitive and emotional processes. Its local circuits among glutamatergic …
highest level cognitive and emotional processes. Its local circuits among glutamatergic …
Rho GTPases: Regulation and roles in cancer cell biology
RB Haga, AJ Ridley - Small GTPases, 2016 - Taylor & Francis
Rho GTPases are well known for their roles in regulating cell migration, and also contribute
to a variety of other cellular responses. They are subdivided into 2 groups: typical and …
to a variety of other cellular responses. They are subdivided into 2 groups: typical and …
Cyclin D–CDK4 kinase destabilizes PD-L1 via cullin 3–SPOP to control cancer immune surveillance
Treatments that target immune checkpoints, such as the one mediated by programmed cell
death protein 1 (PD-1) and its ligand PD-L1, have been approved for treating human …
death protein 1 (PD-1) and its ligand PD-L1, have been approved for treating human …
A ubiquitin ligase mediates target-directed microRNA decay independently of tailing and trimming
INTRODUCTION MicroRNAs (miRNAs) are a class of highly conserved small regulatory
RNAs. After loading into Argonaute (AGO) proteins, miRNAs promote the degradation and …
RNAs. After loading into Argonaute (AGO) proteins, miRNAs promote the degradation and …
A mechanism for the suppression of homologous recombination in G1 cells
A Orthwein, SM Noordermeer, MD Wilson, S Landry… - Nature, 2015 - nature.com
DNA repair by homologous recombination is highly suppressed in G1 cells, to ensure that
mitotic recombination occurs solely between sister chromatids. Although many homologous …
mitotic recombination occurs solely between sister chromatids. Although many homologous …
Harnessing the E3 ligase KEAP1 for targeted protein degradation
Proteolysis targeting chimeras (PROTACs) represent a new class of promising therapeutic
modalities. PROTACs hijack E3 ligases and the ubiquitin-proteasome system (UPS), leading …
modalities. PROTACs hijack E3 ligases and the ubiquitin-proteasome system (UPS), leading …
Prostate cancer–associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4
The bromodomain and extraterminal (BET) family of proteins comprises four members—
BRD2, BRD3, BRD4 and the testis-specific isoform BRDT—that largely function as …
BRD2, BRD3, BRD4 and the testis-specific isoform BRDT—that largely function as …
The role of protein loops and linkers in conformational dynamics and allostery
Proteins are dynamic entities that undergo a plethora of conformational changes that may
take place on a wide range of time scales. These changes can be as small as the rotation of …
take place on a wide range of time scales. These changes can be as small as the rotation of …
Mitochondrial stasis reveals p62-mediated ubiquitination in parkin-independent mitophagy and mitigates nonalcoholic fatty liver disease
It is unknown what occurs if both mitochondrial division and fusion are completely blocked.
Here, we introduced mitochondrial stasis by deleting two dynamin-related GTPases for …
Here, we introduced mitochondrial stasis by deleting two dynamin-related GTPases for …
Enhanced protein degradation by branched ubiquitin chains
HJ Meyer, M Rape - Cell, 2014 - cell.com
Posttranslational modification of cell-cycle regulators with ubiquitin chains is essential for
eukaryotic cell division. Such chains can be connected through seven lysine residues or the …
eukaryotic cell division. Such chains can be connected through seven lysine residues or the …