Allergic rhinitis and its impact on asthma
J Bousquet, P Van Cauwenberge… - Journal of allergy and …, 2001 - jacionline.org
Allergic rhinitis is clinically defined as a symptomatic disorder of the nose induced by an IgE-
mediated inflammation after allergen exposure of the membranes lining the nose. Symptoms …
mediated inflammation after allergen exposure of the membranes lining the nose. Symptoms …
THE HIGH-AFFINITY IgE RECEPTOR (FcϵRI): From Physiology to Pathology
JP Kinet - Annual review of immunology, 1999 - annualreviews.org
▪ Abstract The high affinity receptor for immunoglobulin E (designated FcϵRI) is the member
of the antigen (Ag) receptor superfamily responsible for linking pathogen-or allergen-specific …
of the antigen (Ag) receptor superfamily responsible for linking pathogen-or allergen-specific …
[HTML][HTML] Interferon-regulatory factor 4 is essential for the developmental program of T helper 9 cells
V Staudt, E Bothur, M Klein, K Lingnau, S Reuter… - Immunity, 2010 - cell.com
Summary Interferon-regulatory factor 4 (IRF4) is essential for the development of T helper 2
(Th2) and Th17 cells. Herein, we report that IRF4 is also crucial for the development and …
(Th2) and Th17 cells. Herein, we report that IRF4 is also crucial for the development and …
IL-9-producing T cells: potential players in allergy and cancer
P Angkasekwinai, C Dong - Nature Reviews Immunology, 2021 - nature.com
Abstract IL-9-producing CD4+ T cells have been considered to represent a distinct T helper
cell (TH cell) subset owing to their unique developmental programme in vitro, their …
cell (TH cell) subset owing to their unique developmental programme in vitro, their …
Sensitization to common allergens and its association with allergic disorders at age 4 years: a whole population birth cohort study
SH Arshad, SM Tariq, S Matthews, E Hakim - Pediatrics, 2001 - publications.aap.org
Background. Atopy is defined as the genetic propensity to develop immunoglobulin E
antibodies in response to exposure to allergens and assessed by skin prick test responses …
antibodies in response to exposure to allergens and assessed by skin prick test responses …
New insights into the role of cytokines in asthma
JC Renauld - Journal of clinical pathology, 2001 - jcp.bmj.com
Asthma is a triad of intermittent airway obstruction, bronchial smooth muscle cell
hyperreactivity to bronchoconstrictors, and chronic bronchial inflammation. From an …
hyperreactivity to bronchoconstrictors, and chronic bronchial inflammation. From an …
Expression of interleukin 9 in the lungs of transgenic mice causes airway inflammation, mast cell hyperplasia, and bronchial hyperresponsiveness
UA Temann, GP Geba, JA Rankin… - The Journal of …, 1998 - rupress.org
Interleukin (IL)-9, a pleiotropic cytokine produced by the Th2 subset of T lymphocytes has
been proposed as product of a candidate gene responsible for asthma. Its wide range of …
been proposed as product of a candidate gene responsible for asthma. Its wide range of …
A cluster of seven tightly linked polymorphisms in the IL-13 gene is associated with total serum IgE levels in three populations of white children
PE Graves, M Kabesch, M Halonen, CJ Holberg… - Journal of Allergy and …, 2000 - Elsevier
Background: Increased levels of total serum IgE are a strong risk factor for the development
of asthma. IgE is also involved in host defenses against parasites and fungi. Linkage of total …
of asthma. IgE is also involved in host defenses against parasites and fungi. Linkage of total …
Activin A and TGF-β promote TH9 cell–mediated pulmonary allergic pathology
BACKGROUND: IL-9–secreting (TH9) T cells are thought to represent a distinct T-cell
subset. However, evidence for their functionality in disease is uncertain. OBJECTIVE: To …
subset. However, evidence for their functionality in disease is uncertain. OBJECTIVE: To …