Humans have adapted to the chronic hypoxia of high altitude in several locations, and
recent genome-wide studies have indicated a genetic basis. In some populations, genetic …

High altitude, defined as elevations lying above 2500 m sea level, challenges human
survival and reproduction. This environment provides a natural experimental design wherein …

The origin of Tibetans remains one of the most contentious puzzles in history, anthropology,
and genetics. Analyses of deeply sequenced (30×–60×) genomes of 38 Tibetan highlanders …

The expansion of anatomically modern humans (AMHs) from Africa around 65,000 to 45,000
y ago (ca. 65 to 45 ka) led to the establishment of present-day non-African populations …

The settlement of the Tibetan Plateau epitomizes human adaptation to a high-altitude
environment that poses great challenges to human activity. Here, we reconstruct a 4000 …

Modern humans have experienced explosive population growth in the past thousand years.
We hypothesized that recent human populations have inhabited environments with …

We here report on the existence of Leber's hereditary optic neuropathy (LHON) associated
with peculiar combinations of individually non-pathogenic missense mitochondrial DNA …

Background The genetic relationships reported by recent studies between Sherpas and
Tibetans are controversial. To gain insights into the population history and the genetic basis …

Sherpa people, one of the high-altitude hypoxic adaptive populations, mainly reside in
Nepal and the southern Tibet Autonomous Region. The genetic origin and detailed …

Mitochondrial DNA (mtDNA) is a key player in numerous multifaceted and intricate biological
processes and plays a pivotal role in dissecting the peopling of different populations, due to …