The Ser and Thr kinase AKT, also known as protein kinase B (PKB), was discovered 25
years ago and has been the focus of tens of thousands of studies in diverse fields of biology …

The aim of this review was to summarize current available information about the role of
phosphatidylinositol-3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling …

Insulin resistance is one of the earliest defects in the pathogenesis of type 2 diabetes. Over
the past 50 years, elucidation of the insulin signalling network has provided important …

The class I phosphoinositide 3-kinase (PI3K)–mechanistic target of rapamycin (mTOR)
complex 1 (mTORC1) signaling network directs cellular metabolism and growth. Activation …

The phosphoinositide 3-kinase (PI3K) signaling pathway is one of the most frequently
altered pathways in human cancer and has a critical role in driving tumor initiation and …

Protein kinase B (Akt), similar to many other protein kinases, is at the crossroads of cell
death and survival, playing a pivotal role in multiple interconnected cell signaling …

Prevalence of diabetes, a serious public health problem is rapidly increasing worldwide.
Type-2 diabetes is the common form of diabetes characterized by insulin resistance and …

Protein kinases are key components in cellular signaling pathways as they carry out the
phosphorylation of proteins, primarily on Ser, Thr, and Tyr residues. The catalytic activity of …

Macrophages are a dominant leukocyte population in the tumor microenvironment and
actively promote cancer progression. However, the molecular mechanism underlying the …

Macrophages are able to polarize to proinflammatory M1 or alternative M2 states with
distinct phenotypes and physiological functions. How metabolic status regulates …