Genes disrupted in schizophrenia may be revealed by de novo mutations in affected
persons from otherwise healthy families. Furthermore, during normal brain development …

The vertebrate lens evolved to collect light and focus it onto the retina. In development, the
lens grows through massive elongation of epithelial cells possibly recapitulating the …

βγ-Crystallin-type double clamp (N/D)(N/D) XX (S/T) S motif is an established but sparsely
investigated motif for Ca 2+ binding. A βγ-crystallin domain is formed of two Greek key …

Non-native protein aggregation may occur during manufacturing and storage of protein
therapeutics, and this may decrease drug efficacy or jeopardize patient safety. From a …

The vertebrate eye lens contains high concentrations of crystallins. The dense lenses of fish
are particularly abundant in a class called γM-crystallin whose members are characterized …

Abstract βγ-Crystallins have emerged as a superfamily of structurally homologous proteins
with representatives across the domains of life. A major portion of this superfamily is …

Vertebrate βγ-crystallins belonging to the βγ-crystallin superfamily lack functional Ca2+-
binding sites, while their microbial homologues do not; for example, three out of four sites in …

Background During the last three decades, lens β-and γ-crystallins have found a huge
number of kin from numerous taxonomical sources. Most of these proteins from invertebrates …

The βγ-crystallin superfamily includes highly diverse proteins belonging to all of the
kingdoms of life. Based on structural topology, these proteins are considered to be …

βγ-Crystallins are a superfamily of proteins containing crystallin-type Greek key motifs. Some
βγ-crystallin domains have been shown to bind Ca2+. Hahellin is a newly identified …