One problem area regarding animal models for affective disorders is unclear reproducibility,
including external validity or generalizability. One way to evaluate external validity is with …

Modelling of complex psychiatric disorders, eg, depression and schizophrenia, in animals is
a major challenge, since they are characterized by certain disturbances in functions that are …

Patients with chronic pain often suffer with depressive symptoms, and these two conditions
can be aggravated by each other over time, leading to an increase in symptom intensity and …

The dissociation constants of two related series of 2-(arylimino) imidazolidine and aryl
guanidine α2-adrenoceptor antagonists (35 compounds in total) were measured by …

Searching for improved antagonists of α 2-adrenoceptors, a thorough theoretical study
comparing the aromaticity of phenyl-, pyridinyl-, thiophenyl-and thiazolylguanidinium …

Background: Anxiety and depression, key symptoms of the cocaine withdrawal syndrome in
human addicts, are considered the main factors that precipitate relapse in chronic cocaine …

We have previously identified phenylguanidine and phenyl-2-aminoimidazoline compounds
as high affinity ligands with conflicting functional activity at the α2-adrenoceptor, a G-protein …

The relationship between stress, mood disorders and immune disorders is known, but what
remains to be resolved is why certain individuals are more susceptible than others to suffer …

Purpose/Background Brexpiprazole was approved for adjunctive treatment of major
depressive disorder (MDD) in 2015. Because only a small number of randomized controlled …

The circadian system regulates sleep/wake cycles, metabolism, mood, and other functions. It
also influences medication efficacy. In this study, we studied the chronopharmacological …