Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

Quinoxalinones are a class of heterocyclic compounds which attract extensive attention
owing to their potential in the field of organic synthesis and medicinal chemistry. During the …

Since the 1990s, ionotropic glutamate receptors have served as an outstanding target for
drug discovery research aimed at the discovery of new neurotherapeutic agents. With the …

An organocatalytic method for the modular synthesis of diverse N‐aryl and N‐alkyl
azaheterocycles (indoles, oxindoles, benzimidazoles, and quinoxalinediones) is reported …

L-Glutamic acid is the main excitatory neurotransmitter in the central nervous system (CNS).
Its associated receptors localized on neuronal and non-neuronal cells mediate rapid …

d-Serine is a coagonist of the N-methyl d-aspartate (NMDA) receptor, a key excitatory
neurotransmitter receptor. In the brain, d-serine is synthesized from its l-isomer by serine …

Kainate receptors belong to the family of glutamate receptors ion channels, which are
responsible for the majority of rapid excitatory synaptic transmission in the central nervous …

Src homology-2 domain-containing protein tyrosine phosphatase 1 (SHP1) is mainly
restricted to hematopoietic and epithelial cells and widely accepted as a convergent node …

Twenty-one simplified analogues of the natural product domoic acid were designed,
synthesized, and then characterized at homomeric kainic acid (KA) receptors (GluK1-3, 5) …

Disclosed here is an efficient approach for the preparation of quinoxaline‐2, 3‐diones using
air (O2) as a green oxidant via acid‐promoted self‐photocatalyzed regioselective oxidation …