Novel pathways of vitamin D3, lumisterol 3 (L3), and tachysterol 3 (T3) activation have been
discovered, initiated by CYP11A1 and/or CYP27A1 in the case of L3 and T3. The resulting …

We have previously described new pathways of vitamin D3 activation by CYP11A1 to
produce a variety of metabolites including 20 (OH) D3 and 20, 23 (OH) 2 D3. These can be …

The keratinocytes of the skin are unique in being not only the primary source of vitamin D for
the body, but in possessing both the enzymatic machinery to metabolize the vitamin D …

Vitamin D is the sunshine vitamin. During exposure to sunlight, 7-dehydrocholesterol in the
skin absorbs ultraviolet B (UVB) radiation converting it to previtamin D3. Previtamin D3 …

Ultraviolet B (UVB), in addition to having carcinogenic activity, is required for the production
of vitamin D3 (D3) in the skin which supplies> 90% of the body's requirement. Vitamin D is …

Hydroxyderivatives of vitamin D3, including classical 1, 25 (OH) 2 D3 and novel CYP11A1‑
derived hydroxyderivatives, exert their biological activity by acting as agonists on the vitamin …

The nuclear retinoic acid (RA) receptors (RARα, β and γ) are transcriptional transregulators,
which control the expression of specific gene subsets subsequently to ligand binding and to …

Nonmelanoma skin cancers including basal and squamous cell carcinomas (SCC and BCC)
represent a significant clinical problem due to their relatively high incidence, imposing an …

Vitamin D and calcium are well-established regulators of keratinocyte proliferation and
differentiation. Therefore, it was not a great surprise that deletion of the vitamin D receptor …

Oxidative/nitrosative stress and generation of proinflammatory cytokines are hallmarks of
inflammation. Because chronic inflammation is implicated in several pathologic conditions in …