Role of Bcl-2 family proteins and caspases in the regulation of apoptosis
Apoptosis, or programmed cell death, plays a pivotal role in the elimination of unwanted,
damaged, or infected cells in multicellular organisms and also in diverse biological …
damaged, or infected cells in multicellular organisms and also in diverse biological …
The biochemistry of apoptosis
MO Hengartner - Nature, 2000 - nature.com
Apoptosis—the regulated destruction of a cell—is a complicated process. The decision to
die cannot be taken lightly, and the activity of many genes influence a cell's likelihood of …
die cannot be taken lightly, and the activity of many genes influence a cell's likelihood of …
New benzoxazole derivatives as potential VEGFR-2 inhibitors and apoptosis inducers: Design, synthesis, anti-proliferative evaluation, flowcytometric analysis, and in …
A new series of benzoxazole derivatives were designed and synthesised to have the main
essential pharmacophoric features of VEGFR-2 inhibitors. Cytotoxic activities were …
essential pharmacophoric features of VEGFR-2 inhibitors. Cytotoxic activities were …
Discovery of new pyrimidine-5-carbonitrile derivatives as anticancer agents targeting EGFR WT and EGFR T790M
A new series of pyrimidine-5-carbonitrile derivatives has been designed as ATP mimicking
tyrosine kinase inhibitors of the epidermal growth factor receptor (EGFR). These compounds …
tyrosine kinase inhibitors of the epidermal growth factor receptor (EGFR). These compounds …
Apoptosis in development
Essential to the construction, maintenance and repair of tissues is the ability to induce
suicide of supernumerary, misplaced or damaged cells with high specificity and efficiency …
suicide of supernumerary, misplaced or damaged cells with high specificity and efficiency …
[HTML][HTML] A unified model for apical caspase activation
KM Boatright, M Renatus, FL Scott, S Sperandio… - Molecular cell, 2003 - cell.com
Apoptosis is orchestrated by the concerted action of caspases, activated in a minimal two-
step proteolytic cascade. Existing data suggests that apical caspases are activated by …
step proteolytic cascade. Existing data suggests that apical caspases are activated by …
New quinoxaline-based VEGFR-2 inhibitors: Design, synthesis, and antiproliferative evaluation with in silico docking, ADMET, toxicity, and DFT studies
A new series of 3-methylquinoxaline-based derivatives having the same essential
pharmacophoric features as VEGFR-2 inhibitors have been synthesized and evaluated for …
pharmacophoric features as VEGFR-2 inhibitors have been synthesized and evaluated for …
New quinoxaline derivatives as VEGFR-2 inhibitors with anticancer and apoptotic activity: Design, molecular modeling, and synthesis
Abstract New series of [1, 2, 4] triazolo [4, 3-a] quinoxalin-4 (5H)-one and [1, 2, 4] triazolo [4,
3-a] quinoxaline derivatives have been designed, synthesized, and biologically assessed for …
3-a] quinoxaline derivatives have been designed, synthesized, and biologically assessed for …
New bis ([1, 2, 4] triazolo)[4, 3-a: 3′, 4′-c] quinoxaline derivatives as VEGFR-2 inhibitors and apoptosis inducers: Design, synthesis, in silico studies, and anticancer …
A new series of bis ([1, 2, 4] triazolo)[4, 3-a: 3′, 4′-c] quinoxaline derivatives were
designed and synthesized to have the main essential pharmacophoric features of VEGFR-2 …
designed and synthesized to have the main essential pharmacophoric features of VEGFR-2 …
Design, synthesis, and biological evaluation of new challenging thalidomide analogs as potential anticancer immunomodulatory agents
Thalidomide and its analogs are immunomodulatory drugs that inhibit the production of
certain inflammatory mediators associated with cancer. In the present work, a new series of …
certain inflammatory mediators associated with cancer. In the present work, a new series of …