Continued and sustainable improvements in antimalarial medicines through focused
research and development are essential for the world's future ability to treat and control …

Malaria, caused by parasites of the genus Plasmodium, is one of the leading infectious
diseases in many tropical regions, including Nigeria, a West African country where …

Isoprenoids are the most numerous and structurally diverse family of natural products.
Terpenoids, a class of isoprenoids often isolated from plants, are used as commercial flavor …

Artemisinins are extracted from sweet wormwood (Artemisia annua) and are the most potent
antimalarials available, rapidly killing all asexual stages of Plasmodium falciparum …

Currently, nearly two billion people are at risk of contracting malaria and the incidence of this
disease is dramatically increasing because many Plasmodium falciparum strains, the …

Since ancient times, humankind has had to struggle against the persistent onslaught of
pathogenic microorganisms. Nowadays, malaria is still the most important infectious disease …

Artemisinins were discovered to be highly effective antimalarial drugs shortly after the
isolation of the parent artemisinin in 1971 in China. These compounds combine potent …

Artemisinins form the most important class of antimalarial currently available, particularly
because they are effective against parasites resistant to almost all the other classes. Their …

Terpenoids, also referred to as terpenes, are the largest group of natural compounds. Many
terpenes have biological activities and are used for the treatment of human diseases. The …

Secondary metabolites from plants serve as defense against herbivores, microbes, viruses,
or competing plants. Many medicinal plants have pharmacological activities and may, thus …