Abnormal signaling at corticotropin-releasing factor CRF 1 and CRF 2 receptors might
contribute to the pathophysiology of stress-related disorders such as anxiety, depression …

Studies in mammalian skin have shown expression of the genes for corticotropin‐releasing
hormone (CRH) and the related urocortin peptide, with subsequent production of the …

Urocortins, three paralogs of the stress-related peptide corticotropin-releasing factor (CRF)
found in bony fish, amphibians, birds, and mammals, have unique phylogenies …

Heart failure (HF) imposes significant economic and public health burdens upon modern
society. It is known that disturbances in neurohormonal status play an important role in the …

Stress may cause behavioral and/or psychiatric manifestations such as anxiety and
depression and also impact on the function of different visceral organs, namely the …

Corticotropin-releasing factor (CRF) receptor type 2β (CRFR2β) is expressed in the heart.
Urocortin (Ucn)-I activation of CRFR2β is cardioprotective against ischemic reperfusion (I/R) …

Urocortin (Ucn) is a new member of the corticotropin-releasing factor (CRF) neuropeptide
family and has positive inotropic actions and protective effects against ischemia in the rat …

Corticotropin-releasing factor (CRF) and its paralogues urocortin (Ucn) I,-II, and-III signal by
activating their receptors, CRF receptors (CRFR) 1 and-2, to maintain homeostasis through …

Many of the originally identified cardiovascular 'growth factors' have been demonstrated to
exert a diverse variety of actions within the cardiovascular system, the majority of which are …

Abstract Objective: Interleukin-6 (IL-6) is elevated in the serum of patients with coronary
artery disease (CAD) and acute coronary syndromes (ACS). Intracoronary release of IL-6 …