Malaria in pregnancy: pathogenesis and immunity

SJ Rogerson, L Hviid, PE Duffy, RFG Leke… - The Lancet infectious …, 2007 - thelancet.com
Understanding of the biological basis for susceptibility to malaria in pregnancy was recently
advanced by the discovery that erythrocytes infected with Plasmodium falciparum …

Bacterial superglue enables easy development of efficient virus-like particle based vaccines

S Thrane, CM Janitzek, S Matondo, M Resende… - Journal of …, 2016 - Springer
Abstract Background Virus-like particles (VLPs) represent a significant advance in the
development of subunit vaccines, combining high safety and efficacy. Their particulate …

[HTML][HTML] Protective antibodies against placental malaria and poor outcomes during pregnancy, Benin

NT Ndam, L Denoeud-Ndam… - Emerging infectious …, 2015 - ncbi.nlm.nih.gov
Placental malaria is caused by Plasmodium falciparum–infected erythrocytes that bind to
placental tissue. Binding is mediated by VAR2CSA, a parasite antigen coded by the var …

Placental Sequestration of Plasmodium falciparum Malaria Parasites Is Mediated by the Interaction Between VAR2CSA and Chondroitin Sulfate A on Syndecan-1

M Ayres Pereira, T Mandel Clausen, C Pehrson… - PLoS …, 2016 - journals.plos.org
During placental malaria, Plasmodium falciparum infected erythrocytes sequester in the
placenta, causing health problems for both the mother and fetus. The specific adherence is …

[HTML][HTML] Full-length recombinant Plasmodium falciparum VAR2CSA binds specifically to CSPG and induces potent parasite adhesion-blocking antibodies

P Khunrae, M Dahlbäck, MA Nielsen… - Journal of molecular …, 2010 - Elsevier
Plasmodium falciparum malaria remains one of the world's leading causes of human
suffering and poverty. Each year, the disease takes 1–3 million lives, mainly in sub-Saharan …

Malaria in pregnancy and the newborn

SJ Rogerson - Hot Topics in Infection and Immunity in Children VI, 2010 - Springer
Each year, 40% of the world's population is exposed to the risk of malaria infection.
Approximately 500 million people suffer clinical disease episodes of malaria, and around …

A novel virus-like particle based vaccine platform displaying the placental malaria antigen VAR2CSA

S Thrane, CM Janitzek, MØ Agerbæk, SB Ditlev… - PloS one, 2015 - journals.plos.org
Placental malaria caused by Plasmodium falciparum is a major cause of mortality and
severe morbidity. Clinical testing of a soluble protein-based vaccine containing the parasite …

Evasion of immunity to Plasmodium falciparum malaria by IgM masking of protective IgG epitopes in infected erythrocyte surface-exposed PfEMP1

L Barfod, MB Dalgaard, ST Pleman… - Proceedings of the …, 2011 - National Acad Sciences
Plasmodium falciparum malaria is a major cause of mortality and severe morbidity. Its
virulence is related to the parasite's ability to evade host immunity through clonal antigenic …

The chondroitin sulfate A-binding site of the VAR2CSA protein involves multiple N-terminal domains

M Dahlbäck, LM Jørgensen, MA Nielsen… - Journal of Biological …, 2011 - ASBMB
Malaria during pregnancy is a major health problem for African women. The disease is
caused by Plasmodium falciparum malaria parasites, which accumulate in the placenta by …

Human pregnancy‐associated malaria‐specific B cells target polymorphic, conformational epitopes in VAR2CSA: This article became available OnlineOpen after it …

L Barfod, NL Bernasconi, M Dahlbäck… - Molecular …, 2007 - Wiley Online Library
Pregnancy‐associated malaria (PAM) is caused by Plasmodium falciparum‐infected
erythrocytes (IEs) that bind to chondroitin sulphate A (CSA) in the placenta by PAM …