[HTML][HTML] Ciprofloxacin and levofloxacin attenuate microglia inflammatory response via TLR4/NF-kB pathway

M Zusso, V Lunardi, D Franceschini, A Pagetta… - Journal of …, 2019 - Springer
Background Neuroinflammation is the response of the central nervous system to events that
interfere with tissue homeostasis and represents a common denominator in virtually all …

[HTML][HTML] Inflammatory processes in alzheimer's disease—pathomechanism, diagnosis and treatment: a review

B Twarowski, M Herbet - International journal of molecular sciences, 2023 - mdpi.com
Alzheimer's disease is one of the most commonly diagnosed cases of senile dementia in the
world. It is an incurable process, most often leading to death. This disease is multifactorial …

[HTML][HTML] The emerging role of curcumin in the modulation of TLR-4 signaling pathway: focus on neuroprotective and anti-rheumatic properties

MA Panaro, A Corrado, T Benameur, CF Paolo… - International Journal of …, 2020 - mdpi.com
Natural products have been used in medicine for thousands of years. Given their potential
health benefits, they have gained significant popularity in recent times. The administration of …

[HTML][HTML] Exploring the therapeutic potential of phytochemicals in Alzheimer's disease: Focus on polyphenols and monoterpenes

I Piccialli, V Tedeschi, L Caputo, S D'Errico… - Frontiers in …, 2022 - frontiersin.org
Alzheimer's disease (AD) is a chronic, complex neurodegenerative disorder mainly
characterized by the irreversible loss of memory and cognitive functions. Different …

[HTML][HTML] Immunomodulatory and antiaging mechanisms of resveratrol, rapamycin, and metformin: focus on mTOR and AMPK signaling networks

V Sorrenti, F Benedetti, A Buriani, S Fortinguerra… - Pharmaceuticals, 2022 - mdpi.com
Aging results from the progressive dysregulation of several molecular pathways and mTOR
and AMPK signaling have been suggested to play a role in the complex changes in key …

[HTML][HTML] Alzheimer's disease: natural products as inhibitors of neuroinflammation

OA Olajide, SD Sarker - Inflammopharmacology, 2020 - Springer
Alzheimer's disease (AD) is the most common form of dementia and affects 44 million
people worldwide. New emerging evidence from pre-clinical and clinical investigations …

[HTML][HTML] Natural dietary supplementation of curcumin protects mice brains against ethanol-induced oxidative stress-mediated neurodegeneration and memory …

M Ikram, K Saeed, A Khan, T Muhammad, MS Khan… - Nutrients, 2019 - mdpi.com
The aim of the current study was to explore the underlying neuroprotective mechanisms of
curcumin (50 mg/kg, for six weeks) against ethanol (5 mg/kg ip, for six weeks) induced …

Effects of curcumin on microglial cells

F Ghasemi, H Bagheri, GE Barreto, MI Read… - Neurotoxicity …, 2019 - Springer
Microglia are innate immune system cells which reside in the central nervous system (CNS).
Resting microglia regulate the homeostasis of the CNS via phagocytic activity to clear …

[HTML][HTML] Advances on therapeutic strategies for Alzheimer's disease: from medicinal plant to nanotechnology

NA Hassan, AK Alshamari, AA Hassan, MG Elharrif… - Molecules, 2022 - mdpi.com
Alzheimer's disease (AD) is a chronic dysfunction of neurons in the brain leading to
dementia. It is characterized by gradual mental failure, abnormal cognitive functioning …

Curcumin Attenuates Asthmatic Airway Inflammation and Mucus Hypersecretion Involving a PPARγ‐Dependent NF‐κB Signaling Pathway In Vivo and In Vitro

T Zhu, Z Chen, G Chen, D Wang, S Tang… - Mediators of …, 2019 - Wiley Online Library
Asthma is characterized by airway inflammation and mucus hypersecretion. Curcumin
possessed a potent anti‐inflammatory property involved in the PPARγ‐dependent NF‐κB …