Cells exert, sense, and respond to the different physical forces through diverse mechanisms
and translating them into biochemical signals. The adhesion of cells is crucial in various …

Biomolecular interactions are at the base of all physical processes within living organisms;
the study of these interactions has led to the development of a plethora of different methods …

Small Heat Shock Proteins (sHSPs) are key components of our Protein Quality Control
system and are thought to act as reservoirs that neutralize irreversible protein aggregation …

The collapse of polypeptides is thought important to protein folding, aggregation, intrinsic
disorder, and phase separation. However, whether polypeptide collapse is modulated in …

Molecular catch bonds are ubiquitous in biology and essential for processes like leucocyte
extravasion and cellular mechanosensing. Unlike normal (slip) bonds, catch bonds …

Multiple antibiotic resistances are a major global health threat. The predominant tool for
adaptation in Gram-negative bacteria is the integron. Under stress, it rearranges gene …

Multi-step assembly of individual protein building blocks is key to the formation of essential
higher-order structures inside and outside of cells. Optical tweezers is a technique well …

A facile enzyme-mediated strategy enables site-specific covalent one-step coupling of
genetically tagged luciferase molecules to coenzyme A-modified tobacco mosaic virus (TMV …

Single molecule techniques are particularly well suited for investigating the processes of
protein folding and chaperone assistance. However, current assays provide only a limited …

The heat shock protein 90 (Hsp90) family of chaperones are well-known, highly important
components of the cellular systems which regulate protein homeostasis. Essential in …