Estrogen or 17β-estradiol, a steroid hormone, plays a critical role in the development of
mammary gland via acting through specific receptors. In particular, estrogen receptor-α …

The participation of extranuclear steroid receptor signaling in organ physiology and the
impact for pathobiology has increasingly been demonstrated. Important functions of …

Evasion of apoptosis is a major contributing factor to the development of chemo-and
radiotherapy resistance. Therefore, activation of non-apoptotic programmed cell death …

Tumor metastasis is the leading cause of death among breast cancer patients. PELP1
(proline, glutamic acid and leucine rich protein 1) is a nuclear receptor coregulator that is …

Recurrence of metastatic breast cancer stemming from acquired endocrine and
chemotherapy resistance remains a health burden for women with luminal (ER+) breast …

Most patients with estrogen receptor alpha–positive (ER+) breast cancers initially respond to
treatment but eventually develop therapy resistance with disease progression …

Proline, glutamic acid, and leucine rich protein 1 (PELP1) is a large multi-domain protein
that has been shown to modulate an increasing number of pathways and biological …

Abstract Proline-, glutamic acid-, and leucine-rich protein 1 (PELP1) is a scaffolding protein
that functions as a coregulator of several transcription factors and nuclear receptors …

Estrogen receptor alpha (ERα) is implicated in the initiation and progression of breast
cancer and its transcription depends on the modulation of epigenetic changes at target gene …

Introduction Current clinical strategies for treating hormonal breast cancer involve the use of
anti-estrogens that block estrogen receptor (ER) α functions and aromatase inhibitors that …