Myeloid-derived suppressor cells (MDSCs) are a heterogenic population of immature
myeloid cells with immunosuppressive effects, which undergo massive expansion during …

Head and neck squamous cell carcinoma (HNSCC), an aggressive malignancy, is
characterized by high morbidity and low survival rates with limited therapeutic options …

Abstract Treatment with immune checkpoint inhibitors (ICI) has demonstrated clinical benefit
for a wide range of cancer types. Because only a subset of patients experience clinical …

Cholesterol metabolism produces essential membrane components as well as metabolites
with a variety of biological functions. In the tumour microenvironment, cell-intrinsic and cell …

Neutrophils are the most abundant circulating leukocytes, being the first line of defence
against bacterial and fungal infections. However, neutrophils also contribute to tissue …

Immune evasion and altered metabolism, where glucose utilization is diverted to increased
lactic acid production, are two fundamental hallmarks of cancer. Although lactic acid has …

New evidence has challenged the outdated dogma that neutrophils are a homogeneous
population of short-lived cells. Although neutrophil subpopulations with distinct functions …

Neutrophils are the first line of defense against bacteria and fungi and help combat parasites
and viruses. They are necessary for mammalian life, and their failure to recover after …

AIM To investigate the clinical significance of preoperative systemic immune-inflammation
index (SII) in patients with colorectal cancer (CRC). METHODS A retrospective analysis of …

Myeloid-derived suppressor cells (MDSC) are a diverse population of immature myeloid
cells that have potent immune-suppressive activity. Studies in both mice and humans have …