Lysophospholipid receptors: signaling and biology
▪ Abstract Lysophospholipids (LPs), such as lysophosphatidic acid and sphingosine 1-
phosphate, are membrane-derived bioactive lipid mediators. LPs can affect fundamental …
phosphate, are membrane-derived bioactive lipid mediators. LPs can affect fundamental …
Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network
H Rosen, EJ Goetzl - Nature Reviews Immunology, 2005 - nature.com
Abstract Sphingosine 1-phosphate (S1P) is a biologically active lysophospholipid that
transmits signals through a family of G-protein-coupled receptors to control cellular …
transmits signals through a family of G-protein-coupled receptors to control cellular …
Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate
Sphingosine 1-phosphate (S1P) influences heart rate, coronary artery caliber, endothelial
integrity, and lymphocyte recirculation through five related high affinity G-protein-coupled …
integrity, and lymphocyte recirculation through five related high affinity G-protein-coupled …
[HTML][HTML] Lysophospholipid receptors: signalling, pharmacology and regulation by lysophospholipid metabolism
DM Zu Heringdorf, KH Jakobs - Biochimica et Biophysica Acta (BBA) …, 2007 - Elsevier
The lysophospholipids, sphingosine-1-phosphate (S1P), lysophosphatidic acid (LPA),
sphingosylphosphorylcholine (SPC) and lysophosphatidylcholine (LPC), activate diverse …
sphingosylphosphorylcholine (SPC) and lysophosphatidylcholine (LPC), activate diverse …
Sphingosine-1-phosphate and its receptors: structure, signaling, and influence
The sphingosine-1-phosphate (S1P) receptor signaling system has biological and medical
importance and is the first lipid G protein–coupled receptor (GPCR) structure to be solved to …
importance and is the first lipid G protein–coupled receptor (GPCR) structure to be solved to …
An electrostatic/hydrogen bond switch as the basis for the specific interaction of phosphatidic acid with proteins
Phosphatidic acid (PA) is a minor but important phospholipid that, through specific
interactions with proteins, plays a central role in several key cellular processes. The simple …
interactions with proteins, plays a central role in several key cellular processes. The simple …
Lysophospholipid G protein-coupled receptors
B Anliker, J Chun - Journal of Biological Chemistry, 2004 - ASBMB
The many biological responses documented for lysophospholipids that include
lysophosphatidic acid and sphingosine 1-phosphate can be mechanistically attributed to …
lysophosphatidic acid and sphingosine 1-phosphate can be mechanistically attributed to …
Lysophosphatidic acid binds to and activates GPR92, a G protein-coupled receptor highly expressed in gastrointestinal lymphocytes
K Kotarsky, Å Boketoft, J Bristulf, NE Nilsson… - … of Pharmacology and …, 2006 - ASPET
Here, the ligand binding, activation, and tissue distribution of the orphan G protein-coupled
receptor (GPCR) GPR92 were studied. GPR92 binds and is activated by compounds based …
receptor (GPCR) GPR92 were studied. GPR92 binds and is activated by compounds based …
The type 1 lysophosphatidic acid receptor is a target for therapy in bone metastases
A Boucharaba, CM Serre, J Guglielmi… - Proceedings of the …, 2006 - National Acad Sciences
Platelet-derived lysophosphatidic acid (LPA) supports the progression of breast and ovarian
cancer metastasis to bone. The mechanisms through which LPA promotes bone metastasis …
cancer metastasis to bone. The mechanisms through which LPA promotes bone metastasis …
Dual activity lysophosphatidic acid receptor pan-antagonist/autotaxin inhibitor reduces breast cancer cell migration in vitro and causes tumor regression in vivo
H Zhang, X Xu, J Gajewiak, R Tsukahara, Y Fujiwara… - Cancer research, 2009 - AACR
Signal transduction modifiers that modulate the lysophosphatidic acid (LPA) pathway have
potential as anticancer agents. Herein, we describe metabolically stabilized LPA analogues …
potential as anticancer agents. Herein, we describe metabolically stabilized LPA analogues …