The first full publications on the biological effects of the diphosphonates, later renamed
bisphosphonates, appeared in 1969, so it is timely after 40 years to review the history of their …

The profound effects of the bisphosphonates on calcium metabolism were discovered over
30 years ago, and they are now well established as the major drugs used for the treatment of …

R-Aminophosphonic acids are broadly defined as analogues of amino acids in which the
carboxylic group is replaced by a phosphonic acid or related group (usually phosphonous or …

The discovery and development of the bisphosphonates (BPs) as a major class of drugs for
the treatment of bone diseases has been a fascinating journey that is still not over. In clinical …

The bisphosphonates (BPs) are well established as the treatments of choice for disorders of
excessive bone resorption, including Paget's disease of bone, myeloma and bone …

The x-ray crystal structure of dimeric (+)-bornyl diphosphate synthase, a metal-requiring
monoterpene cyclase from Salvia officinalis, is reported at 2.0-Å resolution. Each monomer …

The isoprenoid biosynthetic pathway is the source of a wide array of products. The pathway
has been highly conserved throughout evolution, and isoprenoids are some of the most …

Bisphosphonates (BPs) are widely used in the treatment of diseases associated with
excessive osteoclast-mediated bone resorption, such as osteoporosis. Although several …

Bisphosphonate drugs (eg, Fosamax and Zometa) are thought to act primarily by inhibiting
farnesyl diphosphate synthase (FPPS), resulting in decreased prenylation of small GTPases …

Considerable effort has focused on the development of selective protein farnesyl transferase
(FTase) and protein geranylgeranyl transferase (GGTase) inhibitors as cancer …