Animal models for COVID-19

C Muñoz-Fontela, WE Dowling, SGP Funnell, PS Gsell… - Nature, 2020 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the aetiological agent of
coronavirus disease 2019 (COVID-19), an emerging respiratory infection caused by the …

SARS-CoV-2 tropism, entry, replication, and propagation: Considerations for drug discovery and development

N Murgolo, AG Therien, B Howell, D Klein… - Advances in Clinical …, 2021 - taylorfrancis.com
Coronaviruses, named for their crown-like spiked surface, are genetically diverse and can
infect multiple animal species, including bats, pigs, cats, rodents, and humans. Aside from …

Reverse-transcribed SARS-CoV-2 RNA can integrate into the genome of cultured human cells and can be expressed in patient-derived tissues

L Zhang, A Richards, MI Barrasa… - Proceedings of the …, 2021 - National Acad Sciences
Prolonged detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
RNA and recurrence of PCR-positive tests have been widely reported in patients after …

A human pluripotent stem cell-based platform to study SARS-CoV-2 tropism and model virus infection in human cells and organoids

L Yang, Y Han, BE Nilsson-Payant, V Gupta, P Wang… - Cell stem cell, 2020 - cell.com
SARS-CoV-2 has caused the COVID-19 pandemic. There is an urgent need for
physiological models to study SARS-CoV-2 infection using human disease-relevant cells …

Neurological complications and infection mechanism of SARS-COV-2

D Wan, T Du, W Hong, L Chen, H Que, S Lu… - Signal Transduction and …, 2021 - nature.com
Abstract Currently, SARS-CoV-2 has caused a global pandemic and threatened many lives.
Although SARS-CoV-2 mainly causes respiratory diseases, growing data indicate that SARS …

Animal and translational models of SARS-CoV-2 infection and COVID-19

MD Johansen, A Irving, X Montagutelli, MD Tate… - Mucosal …, 2020 - nature.com
COVID-19 is causing a major once-in-a-century global pandemic. The scientific and clinical
community is in a race to define and develop effective preventions and treatments. The …

SARS-CoV-2 infection of human iPSC–derived cardiac cells reflects cytopathic features in hearts of patients with COVID-19

JA Perez-Bermejo, S Kang, SJ Rockwood… - Science translational …, 2021 - science.org
Although coronavirus disease 2019 (COVID-19) causes cardiac dysfunction in up to 25% of
patients, its pathogenesis remains unclear. Exposure of human induced pluripotent stem cell …

[HTML][HTML] Androgen signaling regulates SARS-CoV-2 receptor levels and is associated with severe COVID-19 symptoms in men

RM Samuel, H Majd, MN Richter, Z Ghazizadeh… - Cell Stem Cell, 2020 - cell.com
SARS-CoV-2 infection has led to a global health crisis, and yet our understanding of the
disease and potential treatment options remains limited. The infection occurs through …

In vitro and animal models for SARS-CoV-2 research

K Takayama - Trends in pharmacological sciences, 2020 - cell.com
Basic research on SARS-CoV-2 is essential to understand its detailed pathophysiology and
identify best drug targets. Models that can faithfully reproduce the viral life cycle and …

Application of 3D bioprinting in the prevention and the therapy for human diseases

HG Yi, H Kim, J Kwon, YJ Choi, J Jang… - Signal Transduction and …, 2021 - nature.com
Rapid development of vaccines and therapeutics is necessary to tackle the emergence of
new pathogens and infectious diseases. To speed up the drug discovery process, the …