Mechanisms linking hypertriglyceridemia to acute pancreatitis

L Kiss, G Fűr, S Pisipati, P Rajalingamgari… - Acta …, 2023 - Wiley Online Library
Hypertriglyceridemia (HTG) is a metabolic disorder, defined when serum or plasma
triglyceride concentration (seTG) is> 1.7 mM. HTG can be categorized as mild to very severe …

Cholecystokinin (CCK) regulation of pancreatic acinar cells: physiological actions and signal transduction mechanisms

JA Williams - Comprehensive Physiology, 2011 - Wiley Online Library
Pancreatic acinar cells synthesize and secrete about 20 digestive enzymes and ancillary
proteins with the processes that match the supply of these enzymes to their need in …

[HTML][HTML] Fatty acid ethyl esters are less toxic than their parent fatty acids generated during acute pancreatitis

K Patel, C Durgampudi, P Noel, RN Trivedi… - The American Journal of …, 2016 - Elsevier
Although ethanol causes acute pancreatitis (AP) and lipolytic fatty acid (FA) generation
worsens AP, the contribution of ethanol metabolites of FAs, ie, FA ethyl esters (FAEEs), to AP …

Src kinases play a novel dual role in acute pancreatitis affecting severity but no role in stimulated enzyme secretion

B Nuche-Berenguer… - American Journal of …, 2016 - journals.physiology.org
In pancreatic acinar cells, the Src family of kinases (SFK) is involved in the activation of
several signaling cascades that are implicated in mediating cellular processes (growth …

Characterization and predictive value of near infrared 2-deoxyglucose optical imaging in severe acute pancreatitis

C De Oliveira, K Patel, V Mishra, RN Trivedi, P Noel… - PloS one, 2016 - journals.plos.org
Background Studying the uptake of 2-deoxy glucose (2-DG) analogs such as 2-Deoxy-2-
[18F] fluoroglucose (FDG) is a common approach to identify and monitor malignancies and …

Elucidation of the roles of the Src kinases in pancreatic acinar cell signaling

B Nuche‐Berenguer, P Moreno… - Journal of cellular …, 2015 - Wiley Online Library
Recent studies report the Src‐family kinases (SFK's) are important in a number of
physiological and pathophysiological responses of pancreatic acinar cells (pancreatitis …

c-Src regulates cargo transit via the Golgi in pancreatic acinar cells

S Kostenko, CC Heu, JR Yaron, G Singh… - Scientific reports, 2018 - nature.com
The exocrine pancreatic acinar cell is unique for its rapid protein synthesis and packaging in
zymogen granules (ZGs). However, while crucial to the pathogenesis of pancreatitis, the …

质子泵抑制剂对犬胰腺外分泌功能影响的研究

白永愉, 李强, 金约朋, 张启瑜, 周蒙滔 - 肝胆胰外科杂志, 2016 - gdy.qk.wmu.edu.cn
目的探索质子泵抑制剂(proton pump inhibitor, PPI) 对犬胰腺外分泌功能的影响.
方法健康成年犬24 只平均随机分成4 组: 对照组(A 组), 对照给药组(B 组), 胰腺炎组(C 组) …

Hypothermia slows sequential and parallel steps initiated during caerulein pancreatitis

V Mishra, K Patel, RN Trivedi, P Noel, C Durgampudi… - Pancreatology, 2014 - Elsevier
Background and objectives Multiple deleterious signaling cascades are simultaneously
activated in acute pancreatitis (AP), which may limit the success of pharmacologic …