Phase I clinical trials are typically small, uncontrolled studies designed to determine a
maximum tolerated dose of a drug which will be used in further testing. Two divergent …

The explanation and implementation of statistical methods for the medical researcher or
statistician remains an integral part of modern medical research. This book explains the use …

This book takes the standard methods as the starting point, and then describes a wide range
of relatively new approaches and procedures designed to deal with more complicated data …

The Ames Salmonella assay remains the most widely used in vitro genotoxicity assay.
Several statistical methods have been proposed for its analysis [BH Margolin, N. Kaplan, E …

We consider three commonly‐used statistical tests for assessing the association between an
explanatory variable and a measured, binary, or survival‐time, response variable, and …

Statistics for Environmental Biology and Toxicology presents and illustrates statistical
methods appropriate for the analysis of environmental data obtained in biological or …

Welding fumes include agglomerated particles built up of primary nanoparticles. Particles
inhaled through the nose will to some extent be deposited in the protein-rich nasal mucosa …

The industrial chemical acrylamide is suspected to induce potentially heritable genetic
damage. While several studies in rodents have indicated that this substance can damage …

In this paper we are concerned with test procedures for umbrella alternatives in the k‐
sample location problem. Distribution‐free tests are considered for both cases where the …

The importance of chemically induced mutation for human health is discussed briefly, and
the biological basis for the primary in vitro assay for mutagenicity, the Ames Salmonella …