Diabetes is the result of having inadequate supply of functional insulin-producing β cells.
Two possible approaches for replenishing the β cells are:(1) replacement by transplanting …

Cell replacement in adult organs can be achieved through stem cell differentiation or the
replication or transdifferentiation of existing cells. In the adult liver and pancreas, stem cells …

Endogenous pancreatic β cell regeneration is a potential strategy for β cell expansion or
neogenesis to treat diabetes. Regeneration can occur through stimulation of existing β cell …

The gonads have long been considered endocrine glands, producing sex steroids such as
estrogens, androgens, and progesterone (P4) for the sole purpose of sexual differentiation …

The pancreas is a complex organ with exocrine and endocrine components. Many
pathologies impair exocrine function, including chronic pancreatitis, cystic fibrosis and …

The year 2021 marks the 100th anniversary of the discovery of insulin, which has greatly
changed the lives of people with diabetes and become a cornerstone of advances in …

Diabetes is associated with a paucity of insulin-producing β-cells. With the goal of finding
therapeutic routes to treat diabetes, we aim to find molecular and cellular mechanisms …

The process of regeneration serves to heal injury by replacing missing cells. Understanding
regeneration can help us replace cell populations lost during disease, such as the insulin …

The liver and pancreas are critical organs maintaining whole body metabolism. Historically,
the expansion of adult-derived cells from these organs in vitro has proven challenging and …

Identifying pathways for β-cell generation is essential for cell therapy in diabetes. We
investigated the potential of 17β-estradiol (E2) and estrogen receptor (ER) signaling for …