Abstract" Oncometabolite" 2-hydroxyglutarate (2-HG) is an aberrant metabolite found in
tumor cells, exerting a pivotal influence on tumor progression. Recent studies have unveiled …

Physiology and metabolism are often sexually dimorphic, but the underlying mechanisms
remain incompletely understood. Here, we use the intestine of Drosophila melanogaster to …

Nonalcoholic fatty liver disease (NAFLD) and its evolution to inflammatory steatohepatitis
(NASH) are the most common causes of chronic liver damage and transplantation that are …

Cancer cells constantly reprogram their metabolism as the disease progresses. However,
our understanding of the metabolic complexity of cancer remains incomplete. Extensive …

Mitochondrial stress contributes to a range of neurological diseases. Mitonuclear signaling
pathways triggered by mitochondrial stress remodel cellular physiology and metabolism …

Metabolic rewiring is the result of the increasing demands and proliferation of cancer cells,
leading to changes in the biological activities and responses to treatment of cancer cells …

Cancer cells usually exhibit aberrant cell signaling and metabolic reprogramming. However,
mechanisms of crosstalk between these processes remain elusive. Here, we show that in an …

The dramatic growth that occurs during Drosophila larval development requires rapid
conversion of nutrients into biomass. Many larval tissues respond to these biosynthetic …

Individual rare diseases may affect only a few people, making them difficult to recognize,
diagnose or treat by studying humans alone. Instead, model organisms help to validate …

Eukaryotic cells maintain proteostasis through mechanisms that require cytoplasmic and
mitochondrial translation. Genetic defects affecting cytoplasmic translation perturb synapse …