Opioid analgesia and opioid-induced adverse effects: a review

AK Paul, CM Smith, M Rahmatullah, V Nissapatorn… - Pharmaceuticals, 2021 - mdpi.com
Opioids are widely used as therapeutic agents against moderate to severe acute and
chronic pain. Still, these classes of analgesic drugs have many potential limitations as they …

Microglial M1/M2 polarization and metabolic states

R Orihuela, CA McPherson… - British journal of …, 2016 - Wiley Online Library
Microglia are critical nervous system‐specific immune cells serving as tissue‐resident
macrophages influencing brain development, maintenance of the neural environment …

Cannabidiol is a negative allosteric modulator of the cannabinoid CB1 receptor

RB Laprairie, AM Bagher, MEM Kelly… - British journal of …, 2015 - Wiley Online Library
Background and Purpose Cannabidiol has been reported to act as an antagonist at
cannabinoid CB1 receptors. We hypothesized that cannabidiol would inhibit cannabinoid …

The contribution of astrocytes and microglia to traumatic brain injury

IP Karve, JM Taylor, PJ Crack - British journal of pharmacology, 2016 - Wiley Online Library
Traumatic brain injury (TBI) represents a major cause of death and disability in developed
countries. Brain injuries are highly heterogeneous and can also trigger other neurological …

International union of basic and clinical pharmacology. XCVIII. Histamine receptors

P Panula, PL Chazot, M Cowart, R Gutzmer… - Pharmacological …, 2015 - ASPET
Histamine is a developmentally highly conserved autacoid found in most vertebrate tissues.
Its physiological functions are mediated by four 7-transmembrane G protein–coupled …

Dopamine receptors–IUPHAR R eview 13

JM Beaulieu, S Espinoza… - British journal of …, 2015 - Wiley Online Library
The variety of physiological functions controlled by dopamine in the brain and periphery is
mediated by the D 1, D 2, D 3, D 4 and D 5 dopamine GPCRs. Drugs acting on dopamine …

Are cannabidiol and Δ9‐tetrahydrocannabivarin negative modulators of the endocannabinoid system? A systematic review

JM McPartland, M Duncan, V Di Marzo… - British journal of …, 2015 - Wiley Online Library
Based upon evidence that the therapeutic properties of C annabis preparations are not
solely dependent upon the presence of Δ9‐tetrahydrocannabinol (THC), pharmacological …

Neuropeptide Y: A stressful review

F Reichmann, P Holzer - Neuropeptides, 2016 - Elsevier
Stress is defined as an adverse condition that disturbs the homeostasis of the body and
activates adaptation responses. Among the many pathways and mediators involved …

Movers and shakers: cell cytoskeleton in cancer metastasis

CM Fife, JA McCarroll… - British journal of …, 2014 - Wiley Online Library
Metastasis is responsible for the greatest number of cancer deaths. Metastatic disease, or
the movement of cancer cells from one site to another, is a complex process requiring …

Amylin: pharmacology, physiology, and clinical potential

DL Hay, S Chen, TA Lutz, DG Parkes, JD Roth - Pharmacological reviews, 2015 - ASPET
Amylin is a pancreatic β-cell hormone that produces effects in several different organ
systems. Here, we review the literature in rodents and in humans on amylin research since …