Genomes 5 has been completely revised and updated. It is a thoroughly modern textbook
about genomes and how they are investigated. As with previous Genomes editions …

Over a thousand diseases are caused by mutations that alter gene expression levels. The
potential of nuclease-deficient zinc fingers, TALEs or CRISPR fusion systems to treat these …

Spatial positioning is a fundamental principle governing nuclear processes. Chromatin is
organized as a hierarchy from nucleosomes to Mbp chromatin domains (CD) or topologically …

A major challenge of genome-wide association studies (GWASs) is to translate phenotypic
associations into biological insights. Here, we integrate a large GWAS on blood lipids …

Gene expression requires successful communication between enhancer and promoter
regions, whose activities are regulated by a variety of factors and associated with distinct …

Chromosomes in multicellular animals are subdivided into a series of looped domains. In
addition to being the underlying principle for organizing the chromatin fiber, looping is …

Defining chromatin interaction frequencies and topological domains is a great challenge for
the annotations of genome structures. Although the chromosome conformation capture (3C) …

The nucleus is a complex organelle that hosts the genome and is essential for vital
processes like DNA replication, DNA repair, transcription, and splicing. The genome is non …

In many organisms, it remains unclear how X chromosomes are specified for dosage
compensation, since DNA sequence motifs shown to be important for dosage compensation …

A special class of poorly characterized architectural proteins is required for chromatin
topology and enhancer–promoter interactions. Here, we identify Opbp as a new Drosophila …