At each of the brain's vast number of synapses, the presynaptic nerve terminal, synaptic cleft,
and postsynaptic specialization form a transcellular unit to enable efficient transmission of …

For more than 20 years, we have known that Ca2+/calmodulin-dependent protein kinase
(CaMKII) activation is both necessary and sufficient for the induction of long-term …

The study of synaptic plasticity and specifically LTP and LTD is one of the most active areas
of research in neuroscience. In the last 25 years we have come a long way in our …

Scaffolding molecules at the postsynaptic membrane form the foundation of excitatory
synaptic transmission by establishing the architecture of the postsynaptic density (PSD), but …

Glutamate receptors are the most abundant excitatory neurotransmitter receptors in the
brain, responsible for mediating the vast majority of excitatory transmission in neuronal …

The molecular composition of presynaptic and postsynaptic neuronal terminals is dynamic,
and yet long-term stabilizations in postsynaptic responses are necessary for synaptic …

Proteins are essential and abundant components of cellular membranes. Being densely
packed within the limited surface area, proteins fulfil essential tasks for life, which include …

The cleft is an integral part of synapses, yet its macromolecular organization remains
unclear. We show here that the cleft of excitatory synapses exhibits a distinct density profile …

The voltage trace of neuronal activities can follow multiple timescale dynamics that arise
from correlated membrane conductances. Such processes can result in power-law behavior …

Highlights•Synaptic strength depends on nanoscale alignment of release and clustered
receptors.•Diverse mechanisms of altered alignment can contribute to synaptic …