Abstract Purpose of Review The purpose of this article is to review the current understanding
of inflammatory processes on bone, including direct impacts of inflammatory factors on bone …

As the most numerous and long-lived of all bone cells, osteocytes have essential functions
in regulating skeletal health. Through the lacunar-canalicular system, secreted proteins from …

Osteocytes are specialized bone cells that orchestrate skeletal remodeling. Senescent
osteocytes are characterized by an activation of cyclin-dependent kinase inhibitor p16Ink4a …

Cells expressing features of senescence, including upregulation of p21 and p16, appear
transiently following tissue injury, yet the properties of these cells or how they contrast with …

Osteoporosis and type 2 diabetes (T2D) are common diseases that often coexist. While both
of these diseases are associated with poor bone quality and increased fracture risk, their …

Once considered a tissue culture-specific phenomenon, cellular senescence has now been
linked to various biological processes with both beneficial and detrimental roles in humans …

The spreading of senescent cells' burden holds profound implications for frailty, prompting
the exploration of novel therapeutic targets. In this perspective review, we delve into the …

The aging heart is characterized by a number of structural changes leading to ventricular
stiffness, impaired resistance to stress and increased risk of developing heart failure (HF) …

Marrow Adipocyte Senescence in the Pathogenesis of Bone Loss | Current Osteoporosis
Reports Skip to main content SpringerLink Account Menu Find a journal Publish with us Track …

Abstract Histone deacetylase 3 (Hdac3) is an epigenetic regulator of gene expression and
interacts with skeletal transcription factors such as Runx2. We previously reported that …