Enzymatic late‐stage modifications: better late than never
Enzyme catalysis is gaining increasing importance in synthetic chemistry. Nowadays, the
growing number of biocatalysts accessible by means of bioinformatics and enzyme …
growing number of biocatalysts accessible by means of bioinformatics and enzyme …
Molecular understanding of heteronuclear active sites in heme–copper oxidases, nitric oxide reductases, and sulfite reductases through biomimetic modelling
CJ Reed, QN Lam, EN Mirts, Y Lu - Chemical Society Reviews, 2021 - pubs.rsc.org
Heme–copper oxidases (HCO), nitric oxide reductases (NOR), and sulfite reductases (SiR)
catalyze the multi-electron and multi-proton reductions of O2, NO, and SO32−, respectively …
catalyze the multi-electron and multi-proton reductions of O2, NO, and SO32−, respectively …
An N-nitrosating metalloenzyme constructs the pharmacophore of streptozotocin
TL Ng, R Rohac, AJ Mitchell, AK Boal, EP Balskus - Nature, 2019 - nature.com
Small molecules containing the N-nitroso group, such as the bacterial natural product
streptozotocin, are prominent carcinogens, and important cancer chemotherapeutics …
streptozotocin, are prominent carcinogens, and important cancer chemotherapeutics …
Conserved Enzymatic Cascade for Bacterial Azoxy Biosynthesis
J Shi, X Zang, Z Zhao, Z Shen, W Li… - Journal of the …, 2023 - ACS Publications
Azoxy compounds exhibit a wide array of biological activities and possess distinctive
chemical properties. Although there has been considerable interest in the biosynthetic …
chemical properties. Although there has been considerable interest in the biosynthetic …
Molecular mechanism of azoxy bond formation for azoxymycins biosynthesis
YY Guo, ZH Li, TY Xia, YL Du, XM Mao… - Nature Communications, 2019 - nature.com
Azoxy bond is an important chemical bond and plays a crucial role in high energy density
materials. However, the biosynthetic mechanism of azoxy bond remains enigmatic. Here we …
materials. However, the biosynthetic mechanism of azoxy bond remains enigmatic. Here we …
Identification of cyclopropane formation in the biosyntheses of hormaomycins and belactosins: Sequential nitration and cyclopropanation by metalloenzymes
Hormaomycins and belactosins are peptide natural products that contain unusual
cyclopropane moieties. Bioinformatics analysis of the corresponding biosynthetic gene …
cyclopropane moieties. Bioinformatics analysis of the corresponding biosynthetic gene …
Two-Enzyme Pathway Links l-Arginine to Nitric Oxide in N-Nitroso Biosynthesis
Nitric oxide (NO) has wide-ranging roles in biology, but less is known about its role in
building chemical diversity. Here we report a new route to NO from the biosynthetic pathway …
building chemical diversity. Here we report a new route to NO from the biosynthetic pathway …
Structural insight into the catalytic mechanism of the endoperoxide synthase FtmOx1
Abstract The 2‐oxoglutarate (2OG)‐dependent non‐heme enzyme FtmOx1 catalyzes the
endoperoxide biosynthesis of verruculogen. Although several mechanistic studies have …
endoperoxide biosynthesis of verruculogen. Although several mechanistic studies have …
Peroxo-Diiron (III/III) as the reactive intermediate for N-hydroxylation reactions in the multidomain metalloenzyme SznF: evidence from molecular dynamics and …
Upon oxygen activation, the non-heme diiron enzymes can generate various active species
for oxidative transformations. In this work, the catalytic mechanism of the diiron active site …
for oxidative transformations. In this work, the catalytic mechanism of the diiron active site …
Structure and assembly of the diiron cofactor in the heme-oxygenase–like domain of the N-nitrosourea–producing enzyme SznF
MJ McBride, SR Pope, K Hu… - Proceedings of the …, 2021 - National Acad Sciences
In biosynthesis of the pancreatic cancer drug streptozotocin, the tridomain nonheme-iron
oxygenase SznF hydroxylates N δ and N ω′ of N ω-methyl-l-arginine before oxidatively …
oxygenase SznF hydroxylates N δ and N ω′ of N ω-methyl-l-arginine before oxidatively …