Ghrelin, a gastric-derived acylated peptide, regulates energy homeostasis by transmitting
information about peripheral nutritional status to the brain, and is essential for protecting …

The pancreatic islet is a complex mini organ composed of a variety of endocrine cells and
their support cells, which together tightly control blood glucose homeostasis. Changes in …

G-protein-coupled receptor (GPCR)-mediated signal transduction is central to human
physiology and disease intervention, yet the molecular mechanisms responsible for ligand …

The ghrelin receptor or growth hormone secretagogue receptor (GHSR) is a G-protein-
coupled receptor that controls growth hormone and insulin secretion, food intake, and …

Specific arrestin conformations are coupled to distinct downstream effectors, which underlie
the functions of many G-protein-coupled receptors (GPCRs). Here, using unnatural amino …

G-protein-coupled receptors (GPCRs), also known as seven transmembrane receptors, are
the largest family of cell surface receptors in eukaryotes. There are∼ 800 GPCRs in human …

G protein-coupled receptors (GPCRs) are the largest group of receptors involved in cellular
signaling across the plasma membrane and a major class of drug targets. The canonical …

The superfamily of G protein-coupled receptors (GPCRs) mediates a wide range of
physiological responses and serves as an important category of drug targets. Earlier …

G protein-coupled receptors (GPCRs) are integral membrane proteins that play a pivotal role
in signal transduction. Understanding their dynamics is absolutely required to get a clear …

The membrane is an integral component of the G protein-coupled receptor signaling
machinery. Here we demonstrate that lipids regulate the signaling efficacy and selectivity of …