Balanced immune responses in the eyes are crucial to preserve vision. The ocular immune
system has long been considered distinct, owing to the so-called 'immune privilege'of its …

Retinal degeneration is a collection of devastating conditions with progressive loss of vision
which often lead to blindness. Research on retinal microglial cells offers great therapeutic …

Gene therapy is an emerging field of medicine that can target and treat previously
untreatable blinding or lethal diseases. Within the field of ophthalmology, gene therapy has …

The blood-retina barrier (BRB), which is disrupted in diabetic retinopathy (DR) and uveitis, is
an important anatomical characteristic of the retina, regulating nutrient, waste, water, protein …

There is a growing need to better characterise senescent cells in the CNS and retina. The
recently published SenMayo gene panel was developed to identify transcriptomic signatures …

Augmenting the natural melanocortin pathway in mouse eyes with uveitis or diabetes
protects the retinas from degeneration. The retinal cells are protected from oxidative and …

Ferrous ion accumulation and lethal oxidative stress mediate irreversible retinal pigment
epithelial (RPE) cell ferroptosis and subsequent photoreceptor degeneration, a potential key …

There are currently no effective treatments for retinal pigment epithelial (RPE) cell loss in
atrophic AMD (aAMD). However, our research on Prominin-1 (Prom1), a known structural …

PURPOSE To determine if Lmln, a Zinc-metallopeptidase, is important for retinal
homeostasis. DESIGN Basic research in mouse models of retinal degeneration. METHODS …

The dense nerve and thin vascular structure of the corneal tissue provide the refractive
function in healthy eyes. Diabetes mellitus causes ocular complications including corneal …