Sepsis-associated encephalopathy (SAE) is a diffuse brain dysfunction that occurs
secondary to infection in the body without overt CNS infection. SAE is frequently …

Sepsis is a complex of life-threating organ dysfunction in critically ill patients, with a primary
infectious cause or through secondary infection of damaged tissues. The systemic …

Curcumin, an important constituent of turmeric, is known for various biological activities,
primarily due to its antioxidant mechanism. The present study focused on the antibacterial …

The endothelium is a highly dynamic cell layer that is involved in a multitude of physiological
functions, including the control of vascular tone, the movement of cells and nutrients, the …

Infectious diseases may affect brain function and cause encephalopathy even when the
pathogen does not directly infect the central nervous system, known as infectious disease …

Sepsis is one of the most common causes of death, which is closely related to the
uncontrolled systemic inflammation. Dysregulation of M1 macrophage polarization is the …

Sepsis-associated brain dysfunction (SABD) may be the most common type of
encephalopathy in critically ill patients. SABD develops in up to 70% of septic patients and …

The mortality rate of patients who develop acute kidney injury during sepsis nearly doubles.
The effectiveness of therapy is hampered because it is usually initiated only after the onset …

Mitochondrial dysfunction plausibly underlies the aging-associated brain degeneration.
Mitochondria play a pivotal role in cellular bioenergetics and cell-survival. Oxidative stress …

Recent research points to a central role of a neuro-inflammatory cascade in POCD, with
endothelial dysfunction potentially aggravating the insult. Investigating the genomic and …