Tumor associated macrophages (TAMs) are the most frequent immune cells within tumor
microenvironment (TME). There is growing evidence that TAMs are involved in tumor …

Breast cancer is the most commonly diagnosed malignant tumor in women worldwide and
contributes significantly as the primary cause of female cancer related mortality. Hence …

Deleterious inflammation is a primary feature of breast cancer. Accumulating evidence
demonstrates that macrophages, the most abundant leukocyte population in mammary …

During this last decade, adoptive transfer of T lymphocytes genetically modified to express
chimeric antigen receptors (CARs) emerged as a valuable therapeutic strategy in …

Highlights•A limited number of chemokines direct the polarization of CD4+ and CD8+ T
cells.•The CXCL10 is a driver chemokine of effector CD4+ and CD8+ T cells.•CXCL10 …

While an appropriately regulated production of interferons (IFNs) performs a fundamental
role in the defense against coronaviruses such as severe acute respiratory syndrome …

Multiple sclerosis (MS) is characterized by chronic inflammatory response-induced
demyelination of the neurons and degeneration of the axons within the central nervous …

Apelin is an endogenous peptide, which is expressed in a vast board of organs such as the
brain, placenta, heart, lungs, kidneys, pancreas, testis, prostate and adipose tissues. The …

Despite recent advances, breast cancer (BrCa) still affects many women and the impact is
disproportional in African Americans (AA) compared to European Americans (EA) …

T cell-mediated elimination of malignant cells is one cornerstone of endogenous and
therapeutically induced antitumor immunity. Tumors exploit numerous regulatory …