Free radical properties, source and targets, antioxidant consumption and health

G Martemucci, C Costagliola, M Mariano, L D'andrea… - Oxygen, 2022 - mdpi.com
Free radicals have acquired growing importance in the fields of biology and medicine. They
are produced during many different endogenous and exogenous processes. Mitochondria …

Anticancer potential of quercetin: A comprehensive review

A Rauf, M Imran, IA Khan, M ur‐Rehman… - Phytotherapy …, 2018 - Wiley Online Library
Diet plays a key role to maintaining healthy life. Many natural products present in our diet,
such as flavonoids, can prevent the progression of cancer. Quercetin, a distinctive bioactive …

A comprehensive analysis and anti-cancer activities of quercetin in ROS-mediated cancer and cancer stem cells

P Biswas, D Dey, PK Biswas, TI Rahaman… - International journal of …, 2022 - mdpi.com
Reactive oxygen species (ROS) induce carcinogenesis by causing genetic mutations,
activating oncogenes, and increasing oxidative stress, all of which affect cell proliferation …

Quercetin and cancer: new insights into its therapeutic effects on ovarian cancer cells

A Vafadar, Z Shabaninejad, A Movahedpour, F Fallahi… - Cell & bioscience, 2020 - Springer
Ovarian cancer is known as a serious malignancy that affects women's reproductive tract
and can considerably threat their health. A wide range of molecular mechanisms and …

β-Caryophyllene: a sesquiterpene with countless biological properties

F Francomano, A Caruso, A Barbarossa, A Fazio… - Applied sciences, 2019 - mdpi.com
β-Caryophyllene (BCP), a natural bicyclic sesquiterpene, is a selective phytocannabinoid
agonist of type 2 receptors (CB2-R). It isn't psychogenic due to the absence of an affinity to …

Small molecules regulating reactive oxygen species homeostasis for cancer therapy

J Zhang, D Duan, ZL Song, T Liu… - Medicinal Research …, 2021 - Wiley Online Library
Elevated intracellular reactive oxygen species (ROS) and antioxidant defense systems have
been recognized as one of the hallmarks of cancer cells. Compared with normal cells …

Synthesis, chemical–physical characterization, and biomedical applications of functional gold nanoparticles: A review

I Ielo, G Rando, F Giacobello, S Sfameni, A Castellano… - Molecules, 2021 - mdpi.com
Relevant properties of gold nanoparticles, such as stability and biocompatibility, together
with their peculiar optical and electronic behavior, make them excellent candidates for …

Quercetin as a JAK–STAT inhibitor: a potential role in solid tumors and neurodegenerative diseases

H Zalpoor, M Nabi-Afjadi, R Forghaniesfidvajani… - Cellular & molecular …, 2022 - Springer
The Janus kinase–signal transducer and activator of transcription (JAK–STAT) pathway is
involved in many immunological processes, including cell growth, proliferation …

Plant-derived natural products in cancer research: extraction, mechanism of action, and drug formulation

WH Talib, I Alsalahat, S Daoud, RF Abutayeh… - Molecules, 2020 - mdpi.com
Cancer is one of the main causes of death globally and considered as a major challenge for
the public health system. The high toxicity and the lack of selectivity of conventional …

Rutin is a low micromolar inhibitor of SARS-CoV-2 main protease 3CLpro: Implications for drug design of quercetin analogs

B Rizzuti, F Grande, F Conforti, A Jimenez-Alesanco… - Biomedicines, 2021 - mdpi.com
The pandemic, due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has
stimulated the search for antivirals to tackle COVID-19 infection. Molecules with known …