Genetics of gastric cancer

MH McLean, EM El-Omar - Nature reviews Gastroenterology & …, 2014 - nature.com
Gastric cancer remains highly prevalent and accounts for a notable proportion of global
cancer mortality. This cancer is also associated with poor survival rates. Understanding the …

A comprehensive survey of genomic alterations in gastric cancer reveals systematic patterns of molecular exclusivity and co-occurrence among distinct therapeutic …

N Deng, LK Goh, H Wang, K Das, J Tao, IB Tan… - Gut, 2012 - gut.bmj.com
Objective Gastric cancer is a major gastrointestinal malignancy for which targeted therapies
are emerging as treatment options. This study sought to identify the most prevalent …

[HTML][HTML] Carcinoma of the stomach: A review of epidemiology, pathogenesis, molecular genetics and chemoprevention

S Nagini - World journal of gastrointestinal oncology, 2012 - ncbi.nlm.nih.gov
Carcinoma of the stomach is still the second most common cause of cancer death
worldwide, although the incidence and mortality have fallen dramatically over the last 50 …

MicroRNA-375 is downregulated in gastric carcinomas and regulates cell survival by targeting PDK1 and 14-3-3ζ

Y Tsukamoto, C Nakada, T Noguchi, M Tanigawa… - Cancer research, 2010 - AACR
We investigated expression profiles of microRNA (miRNA) in gastric carcinomas by use of a
miRNA microarray platform covering a total of 470 human miRNAs. We identified 39 …

Immunotherapy against several tumors, such as lung cancer, including NSCLC

T Weinschenk, S Walter, J Fritsche, S Colette… - US Patent …, 2018 - Google Patents
A method of treating a patient who has non-small cell lung carcinoma (NSCLC), lung cancer,
gastric cancer, and/or glioblastoma includes administering to said patient a composition …

Upregulated INHBA expression is associated with poor survival in gastric cancer

Q Wang, YG Wen, DP Li, J Xia, CZ Zhou, DW Yan… - Medical oncology, 2012 - Springer
Expression microarrays are widely used for investigating the candidate molecular targets in
human cancer. While genome-wide expression signatures screened by gene set enrichment …

Novel immunotherapy against several tumors, such as lung cancer, including nsclc

T Weinschenk, S Walter, J Fritsche, S Colette, H Singh - 2015 - Google Patents
The present invention relates to peptides, nucleic acids and cells for use in
immunotherapeutic methods. In particular, the present invention relates to the …

Roles of farnesyl-diphosphate farnesyltransferase 1 in tumour and tumour microenvironments

NT Ha, CH Lee - Cells, 2020 - mdpi.com
Farnesyl-diphosphate farnesyltransferase 1 (FDFT1, squalene synthase), a membrane-
associated enzyme, synthesizes squalene via condensation of two molecules of farnesyl …

Heterogeneity of amplification of HER2, EGFR, CCND1 and MYC in gastric cancer

P Stahl, C Seeschaaf, P Lebok, A Kutup… - BMC …, 2015 - Springer
Background Intra-tumor heterogeneity is a potential cause for failure of targeted therapy in
gastric cancer, but the extent of heterogeneity of established (HER2) or potential (EGFR …

SEC61G promotes breast cancer development and metastasis via modulating glycolysis and is transcriptionally regulated by E2F1

J Ma, Z He, H Zhang, W Zhang, S Gao, X Ni - Cell death & disease, 2021 - nature.com
Breast cancer is the most common cancer in women and its incidence rates are rapidly
increasing in China. Understanding the molecular mechanisms of breast cancer …