Glomerular hyperfiltration

M Cortinovis, N Perico, P Ruggenenti… - Nature reviews …, 2022 - nature.com
Circulating blood is filtered across the glomerular barrier to form an ultrafiltrate of plasma in
the Bowman's space. The volume of glomerular filtration adjusted by time is defined as the …

Molecular mechanisms that control interstitial fibrosis in the pressure-overloaded heart

EE Creemers, YM Pinto - Cardiovascular research, 2011 - academic.oup.com
When considering the pathological steps in the progression from cardiac overload towards
the full clinical syndrome of heart failure, it is becoming increasingly clear that the …

The clinical importance of nephron mass

VA Luyckx, BM Brenner - Journal of the American Society of …, 2010 - journals.lww.com
Abundant evidence supports the association between low birth weight (LBW) and renal
dysfunction in humans. Anatomic measurements of infants, children, and adults show …

[HTML][HTML] The impact of kidney development on the life course: a consensus document for action

TLB Weight… - Nephron. Clinical …, 2017 - ncbi.nlm.nih.gov
Hypertension and chronic kidney disease (CKD) have a significant impact on global
morbidity and mortality. The Low Birth Weight and Nephron Number Working Group has …

Donor-recipient weight and sex mismatch and the risk of graft loss in renal transplantation

AJ Miller, BA Kiberd, IP Alwayn, A Odutayo… - Clinical Journal of the …, 2017 - journals.lww.com
Results Of 115,124 kidney transplant recipients, 21,261 developed death-censored graft
failure (median graft survival time was 3.8 years; quartile 1 to 3, 0.0 to 14.8 years). After …

Weight gain after renal transplantation is a risk factor for patient and graft outcome

AE El-Agroudy, EW Wafa, OE Gheith… - …, 2004 - journals.lww.com
Background. The present study aimed to evaluate the effect of weight gain after
transplantation on patient and graft outcome. Methods. Patients receiving kidney transplants …

Age at graft loss after pediatric kidney transplantation: exploring the high-risk age window

KJ Van Arendonk, NT James, BJ Boyarsky… - Clinical Journal of the …, 2013 - journals.lww.com
Results Among 16,266 recipients, graft loss during ages≥ 17 and< 24 years was greater
than that for both 3–17 years (adjusted hazard ratio [aHR], 1.61; P< 0.001) and≥ 24 years …

Kidney and recipient weight incompatibility reduces long-term graft survival

M Giral, Y Foucher, G Karam, Y Labrune… - Journal of the …, 2010 - journals.lww.com
Long-term function of kidney allografts depends on multiple variables, one of which may be
the compatibility in size between the graft and the recipient. Here, we assessed the long …

[HTML][HTML] Hypertension in kidney transplant recipients

ME Alexandrou, CJ Ferro, I Boletis… - World Journal of …, 2022 - ncbi.nlm.nih.gov
Kidney transplantation is considered the treatment of choice for end-stage kidney disease
patients. However, the residual cardiovascular risk remains significantly higher in kidney …

[HTML][HTML] Low nephron number and its clinical consequences

VA Luyckx, K Shukha, BM Brenner - … Maimonides medical journal, 2011 - ncbi.nlm.nih.gov
Epidemiologic studies now strongly support the hypothesis, proposed over two decades
ago, that developmental programming of the kidney impacts an individual's risk for …