Although more than 100 types of RNA modification have been described thus far, most of
them were thought to be rare in mRNAs and in regulatory noncoding RNAs. Recent …

RNA tailing, or the addition of non-templated nucleotides to the 3′ end of RNA, is the most
frequent and conserved type of RNA modification. The addition of tails and their composition …

Uridylation occurs pervasively on mRNAs, yet its mechanism and significance remain
unknown. By applying TAIL-seq, we identify TUT4 and TUT7 (TUT4/7), also known as …

The mechanisms of gene expression regulation by miRNAs have been extensively studied.
However, the regulation of miRNA function and decay has long remained enigmatic. Only …

Nonsense-mediated mRNA decay (NMD), which is arguably the best-characterized
translation-dependent regulatory pathway in mammals, selectively degrades mRNAs as a …

During the maternal-to-zygotic transition (MZT), maternal RNAs are actively degraded and
replaced by newly synthesized zygotic transcripts in a highly coordinated manner. However …

Uridylation of various cellular RNA species at the 3′ end has been generally linked to RNA
degradation. In mammals, uridylated pre‐let‐7 miRNAs and mRNAs are targeted by the 3 …

RNA uridylation is a potent and widespread posttranscriptional regulator of gene
expression. RNA uridylation has been detected in a range of eukaryotes including …

The process of mRNA decay and surveillance is considered to be one of the main
posttranscriptional gene expression regulation platforms in eukaryotes. The degradation of …

The bacterial Hfq protein is a versatile modulator of RNA function and is particularly
important for regulation mediated by small non-coding RNAs. Hfq is a bacterial Sm protein …