Breaking the final barrier: Evolution of cationic and ionizable lipid structure in lipid nanoparticles to escape the endosome
In the past decade, nucleic acid therapies have seen a boon in development and clinical
translation largely due to advances in nanotechnology that have enabled their safe and …
translation largely due to advances in nanotechnology that have enabled their safe and …
Optimizing CAR-T cell therapy for solid tumors: current challenges and potential strategies
K Ai, B Liu, X Chen, C Huang, liping Yang… - Journal of Hematology & …, 2024 - Springer
Chimeric antigen receptor (CAR)-T cell therapy demonstrates substantial efficacy in various
hematological malignancies. However, its application in solid tumors is still limited. Clinical …
hematological malignancies. However, its application in solid tumors is still limited. Clinical …
In situ engineering of mRNA-CAR T cells using spleen-targeted ionizable lipid nanoparticles to eliminate cancer cells
Y Li, Y Tian, C Li, W Fang, X Li, Z Jing, Z Yang… - Nano Today, 2024 - Elsevier
Chimeric antigen receptor (CAR) T cell therapy has implemented impressive advances in
the treatment of B-cell lymphoma. However, the complex production process of CAR T cells …
the treatment of B-cell lymphoma. However, the complex production process of CAR T cells …
Steering the course of CAR T cell therapy with lipid nanoparticles
Lipid nanoparticles (LNPs) have proven themselves as transformative actors in chimeric
antigen receptor (CAR) T cell therapy, surpassing traditional methods and addressing …
antigen receptor (CAR) T cell therapy, surpassing traditional methods and addressing …
Tuning Lipid Nanoparticles for RNA Delivery to Extrahepatic Organs
RNA therapeutics have been successfully transitioned into clinical applications. Lipid
nanoparticles (LNPs) are widely employed as nonviral delivery vehicles for RNA …
nanoparticles (LNPs) are widely employed as nonviral delivery vehicles for RNA …
[HTML][HTML] Recent Advancements in mRNA Vaccines: From Target Selection to Delivery Systems
Z Wu, W Sun, H Qi - Vaccines, 2024 - mdpi.com
mRNA vaccines are leading a medical revolution. mRNA technologies utilize the host's own
cells as bio-factories to produce proteins that serve as antigens. This revolutionary approach …
cells as bio-factories to produce proteins that serve as antigens. This revolutionary approach …
Current landscape of mRNA technologies and delivery systems for new modality therapeutics
RM Lu, HE Hsu, SJLP Perez, M Kumari… - Journal of Biomedical …, 2024 - Springer
Realizing the immense clinical potential of mRNA-based drugs will require continued
development of methods to safely deliver the bioactive agents with high efficiency and …
development of methods to safely deliver the bioactive agents with high efficiency and …
Emerging strategies for nanomedicine in autoimmunity
AS Thatte, MM Billingsley, D Weissman… - Advanced Drug Delivery …, 2024 - Elsevier
Autoimmune disorders have risen to be among the most prevalent chronic diseases across
the globe, affecting approximately 5–7% of the population. As autoimmune diseases steadily …
the globe, affecting approximately 5–7% of the population. As autoimmune diseases steadily …
Recent advances in polymeric and lipid stimuli-responsive nanocarriers for cell-based cancer immunotherapy
A Gharatape, B Amanzadi, F Mohamadi… - …, 2024 - Taylor & Francis
Conventional cancer therapy has major limitations, including non-specificity, unavoidable
side effects, low specific tumor accumulation and systemic toxicity. In recent years, more …
side effects, low specific tumor accumulation and systemic toxicity. In recent years, more …
Tuning extracellular fluid viscosity to enhance transfection efficiency
Gene therapies and cellular programming rely on effective cell transfection. Despite
continuous advancements in carrier development and transfection techniques to enhance …
continuous advancements in carrier development and transfection techniques to enhance …