Heart failure: diagnosis, management and utilization

AA Inamdar, AC Inamdar - Journal of clinical medicine, 2016 - mdpi.com
Despite the advancement in medicine, management of heart failure (HF), which usually
presents as a disease syndrome, has been a challenge to healthcare providers. This is …

Stem cell therapy in heart diseases–cell types, mechanisms and improvement strategies

P Müller, H Lemcke, R David - Cellular Physiology and Biochemistry, 2018 - karger.com
A large number of clinical trials have shown stem cell therapy to be a promising therapeutic
approach for the treatment of cardiovascular diseases. Since the first transplantation into …

Cell therapy trials for heart regeneration—lessons learned and future directions

P Menasché - Nature Reviews Cardiology, 2018 - nature.com
The effects of cell therapy on heart regeneration in patients with chronic cardiomyopathy
have been assessed in several clinical trials. These trials can be categorized as those using …

Clinical studies of cell therapy in cardiovascular medicine: recent developments and future directions

MN Banerjee, R Bolli, JM Hare - Circulation research, 2018 - Am Heart Assoc
Given the rising prevalence of cardiovascular disease worldwide and the limited therapeutic
options for severe heart failure, novel technologies that harness the regenerative capacity of …

Cell therapy for cardiac repair—lessons from clinical trials

A Behfar, R Crespo-Diaz, A Terzic… - Nature Reviews …, 2014 - nature.com
The global impetus to identify curative therapies has been fuelled by the unmet needs of
patients in the context of a growing heart failure pandemic. To date, regeneration trials in …

Cell therapy in patients with heart failure: a comprehensive review and emerging concepts

R Bolli, M Solankhi, XL Tang… - Cardiovascular research, 2022 - academic.oup.com
This review summarizes the results of clinical trials of cell therapy in patients with heart
failure (HF). In contrast to acute myocardial infarction (where results have been consistently …

All roads lead to Rome (the heart): cell retention and outcomes from various delivery routes of cell therapy products to the heart

J Li, S Hu, D Zhu, K Huang, X Mei… - Journal of the …, 2021 - Am Heart Assoc
In the past decades, numerous preclinical studies and several clinical trials have evidenced
the feasibility of cell transplantation in treating heart diseases. Over the years, different …

Clinical imaging in regenerative medicine

AV Naumova, M Modo, A Moore, CE Murry… - Nature …, 2014 - nature.com
In regenerative medicine, clinical imaging is indispensable for characterizing damaged
tissue and for measuring the safety and efficacy of therapy. However, the ability to track the …

[HTML][HTML] Drug and cell delivery for cardiac regeneration

CL Hastings, ET Roche, E Ruiz-Hernandez… - Advanced drug delivery …, 2015 - Elsevier
The spectrum of ischaemic cardiomyopathy, encompassing acute myocardial infarction to
congestive heart failure is a significant clinical issue in the modern era. This group of …

Stem cell imaging: from bench to bedside

PK Nguyen, J Riegler, JC Wu - Cell stem cell, 2014 - cell.com
Although cellular therapies hold great promise for the treatment of human disease, results
from several initial clinical trials have not shown a level of efficacy required for their use as a …