Aging is a major cause of many degenerative diseases. The most intuitive consequence of
aging is mainly manifested on the skin, resulting in cumulative changes in skin structure …

Autophagy is a conserved lysosomal degradation pathway where cellular components are
dynamically degraded and re-processed to maintain physical homeostasis. However, the …

Therapeutic resistance and metastatic progression are responsible for the majority of cancer
mortalities. In particular, the development of resistance is a significant barrier to the efficacy …

Appropriate autophagy has protective effects on ischemic nerve tissue, while excessive
autophagy may cause cell death. The inflammatory response plays an important role in the …

Autophagy is an evolutionarily conserved lysosome-or vacuole-dependent catabolic
pathway in eukaryotes. Autophagy functions basally for cellular quality control and is …

The cell‐to‐cell transfer of α‐synuclein (α‐Syn) greatly contributes to Parkinson's disease
(PD) pathogenesis and underlies the spread of α‐Syn pathology. During this process …

Autophagy, defined as a scavenging process of protein aggregates and damaged
organelles mediated by lysosomes, plays a significant role in the quality control of …

Metformin is the first-line option for treating newly diagnosed diabetic patients and also
involved in other pharmacological actions, including antitumor effect, anti-aging effect …

Neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease
(PD), are characterized by progressive memory loss and motor impairment. Aging is a major …

Mitogen-activated protein (MAP) kinases are a central component in signaling networks in a
multitude of mammalian cell types. This review covers recent advances on specific functions …