The discovery of kisspeptin as a critical central regulatory factor of GnRH release has given
people a novel understanding of the neuroendocrine regulation in human reproduction …

The concept that different systems control episodic and surge secretion of gonadotropin‐
releasing hormone (GnRH) was well established by the time that GnRH was identified and …

The pulsatile release of luteinizing hormone (LH) is critical for mammalian fertility. However,
despite several decades of investigation, the identity of the neuronal network generating …

The mechanism by which arcuate nucleus kisspeptin (ARN KISS) neurons co-expressing
glutamate, neurokinin B, and dynorphin intermittently synchronize their activity to generate …

Colocalization of small-molecule and neuropeptide transmitters is common throughout the
nervous system of all animals. The resulting co-transmission, which provides conjoint …

The pulsatile release of GnRH and LH secretion is essential for fertility in all mammals.
Pulses of LH occur approximately every hour in follicular-phase females and every 2 to 3 …

In the past decade since kisspeptin/neurokinin B/dynorphin (KNDy) cells were first identified
in the mammalian hypothalamus, a plethora of new research has emerged adding insights …

Mammalian reproductive function depends upon a neuroendocrine circuit that evokes the
pulsatile release of gonadotropin hormones (luteinizing hormone and follicle-stimulating …

A hypothalamic pulse generator located in the arcuate nucleus controls episodic release of
gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH) and is essential for …

The identification of loss-of-function mutations in MKRN3 in patients with central precocious
puberty in association with the decrease in MKRN3 expression in the medial basal …