Primary cilia are solitary, microtubule-based protrusions of the cell surface that play
fundamental roles as photosensors, mechanosensors and biochemical sensors. Primary …

Cilia are microtubule-based organelles located at the cell surface of many eukaryotic cell
types. Cilia control different cellular functions ranging from motility (for motile cilia) to signal …

Regulated trafficking of G protein–coupled receptors (GPCRs) controls cilium-based
signaling pathways. β-Arrestin, a molecular sensor of activated GPCRs, and the BBSome, a …

Establishment and maintenance of the primary cilium as a signaling-competent organelle
requires a high degree of fine tuning, which is at least in part achieved by a variety of post …

Tumor-associated macrophages (TAMs) play crucial roles in tumor progression and immune
responses. However, mechanisms of driving TAMs to antitumor function remain unknown …

Microtubule depolymerases of the kinesin‐13 family play important roles in various cellular
processes and are frequently overexpressed in different cancer types. Despite the …

The primary cilium is a microtubule‐based sensory organelle that dynamically links
signalling pathways to cell differentiation, growth, and development. Genetic defects of …

Developmental defects in motile cilia, arising from genetic abnormalities in one or more
ciliary genes, can lead to a common ciliopathy known as primary ciliary dyskinesia (PCD) …

The primary cilium is a solitary, microtubule-based membrane protrusion extending from the
surface of quiescent cells that senses the cellular environment and triggers specific cellular …

Primary cilia are crucial for signal transduction in a variety of pathways, including hedgehog
and Wnt. Disruption of primary cilia formation (ciliogenesis) is linked to numerous …